Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is Evolutionary History?02:35

What is Evolutionary History?

43.6K
Scientists record evolutionary history by analyzing fossil, morphological, and genetic data. The fossil record documents the history of life on Earth and provides evidence for evolution. However, both fossil and living organisms offer evidence that outlines Earth’s evolutionary history.
43.6K
Antibiotic Selection00:57

Antibiotic Selection

60.0K
Overview
60.0K
Evolutionary Psychology01:20

Evolutionary Psychology

1.0K
Evolutionary psychology explores the origins of human behavior and mental processes by framing them within the context of natural selection, a theory famously propounded by Charles Darwin. This field asserts that many behaviors common across human societies — ranging from instinctive fear reactions to complex social interactions — arose as evolutionary adaptations. These adaptations enhanced the survival and reproductive success of our ancestors, thereby becoming embedded in the...
1.0K
Emerging Adulthood01:27

Emerging Adulthood

696
Jeffrey Arnett's concept of emerging adulthood offers a framework to understand the unique developmental stage between adolescence and full-fledged adulthood, generally from ages 18 to 25. This period is marked by extensive exploration and shifts in identity, relationships, and career choices, a process known in psychology as role experimentation. Emerging adulthood reflects the evolving cultural expectations surrounding adulthood and the dynamic process of personal transformation during...
696
Criticisms of the Evolutionary Perspective01:23

Criticisms of the Evolutionary Perspective

375
In a study where individuals posing as strangers offered compliments and proposed casual sex to students, the responses differed significantly based on gender. Not a single woman accepted the proposal, while 70% of the men agreed. This outcome provides a useful scenario to explore through the lens of evolutionary psychology and social learning theory, highlighting the diverse perspectives on human sexual behaviors.
Evolutionary psychology provides one explanation for these findings, suggesting...
375
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

7.0K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
7.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tandem-sgRNA Provides an Effective Reverse Genetic Approach for Suppression of <i>Streptomyces</i> Biosynthetic Gene Clusters and Secondary Metabolism.

ACS synthetic biology·2026
Same author

Complex multicellularity is linked with expanded specialized metabolite production in microorganisms.

Nature microbiology·2026
Same author

When context matters: community and environmental context to elicit natural products.

Essays in biochemistry·2026
Same author

Large-scale investigation for antimicrobial activity reveals newly-identified defensive species across the healthy skin microbiome.

Nature communications·2026
Same author

Author Correction: Streptomyces produce a diphtheria toxin-like exotoxin that targets insects.

Nature microbiology·2026
Same author

PARAS: High-Accuracy Machine Learning of Substrate Specificities in Nonribosomal Peptide Synthetases.

JACS Au·2026

Related Experiment Video

Updated: Feb 4, 2026

An Emerging Target Paradigm to Evoke Fast Visuomotor Responses on Human Upper Limb Muscles
09:27

An Emerging Target Paradigm to Evoke Fast Visuomotor Responses on Human Upper Limb Muscles

Published on: August 25, 2020

4.8K

Emerging evolutionary paradigms in antibiotic discovery.

Marc G Chevrette1,2, Cameron R Currie3

  • 1Department of Genetics, University of Wisconsin-Madison, Madison, WI, USA.

Journal of Industrial Microbiology & Biotechnology
|October 1, 2018
PubMed
Summary

Discovering new antibiotics is crucial due to resistant pathogens. Understanding the ecology and evolution of microbe-derived antibiotics offers a rational approach for novel drug discovery.

Keywords:
AntibioticsEcologyEvolutionNatural productsSecondary metabolism

More Related Videos

A Novel High-Throughput Ex Vivo Ovine Skin Wound Model for Testing Emerging Antibiotics
08:30

A Novel High-Throughput Ex Vivo Ovine Skin Wound Model for Testing Emerging Antibiotics

Published on: September 16, 2022

2.5K
Antibiotic Dereplication Using the Antibiotic Resistance Platform
10:49

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Published on: October 17, 2019

11.7K

Related Experiment Videos

Last Updated: Feb 4, 2026

An Emerging Target Paradigm to Evoke Fast Visuomotor Responses on Human Upper Limb Muscles
09:27

An Emerging Target Paradigm to Evoke Fast Visuomotor Responses on Human Upper Limb Muscles

Published on: August 25, 2020

4.8K
A Novel High-Throughput Ex Vivo Ovine Skin Wound Model for Testing Emerging Antibiotics
08:30

A Novel High-Throughput Ex Vivo Ovine Skin Wound Model for Testing Emerging Antibiotics

Published on: September 16, 2022

2.5K
Antibiotic Dereplication Using the Antibiotic Resistance Platform
10:49

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Published on: October 17, 2019

11.7K

Area of Science:

  • Microbiology
  • Evolutionary Biology
  • Natural Product Chemistry

Background:

  • Antibiotics are vital medicines, but new discoveries are scarce despite rising antimicrobial resistance.
  • Actinobacteria-derived natural products have historically been a key source of antibiotics.
  • The ecological and evolutionary drivers of antibiotic chemistry are poorly understood.

Purpose of the Study:

  • To review the ecology of antibiotics in microbial defensive symbioses.
  • To explore evolutionary processes shaping antibiotic chemical diversity and activity.
  • To propose an ecology- and evolution-informed strategy for discovering new antibiotics.

Main Methods:

  • Literature review focusing on microbial ecology and evolutionary mechanisms.
  • Analysis of biosynthetic pathway transmission (vertical and lateral).
  • Examination of factors influencing antibiotic efficacy, specificity, and toxicity.

Main Results:

  • Antibiotic production is linked to microbial defensive symbioses.
  • Evolutionary dynamics, including gene transfer, drive antibiotic diversity.
  • Efficacy, specificity, and toxicity evolve through complex interactions.

Conclusions:

  • Understanding microbial interactions and their metabolites is key to antibiotic discovery.
  • An ecological and evolutionary framework can guide the rational search for novel antibiotics.
  • This approach offers an alternative to traditional methods for combating antimicrobial resistance.