Related Experiment Video
Updated: Feb 4, 2026

A Protocol for Explant Cultures of IDH1-mutant Diffuse Low-grade Gliomas
Published on: May 9, 2025
Awake resection of a left operculo-insular low-grade glioma guided by cortico-subcortical mapping
Thiébaud Picart1, Hugues Duffau1,2
11Department of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center, Montpellier.
Abstract:
A 30-year-old right-handed female medical doctor experienced generalized seizures. MRI showed a left operculo-insular low-grade glioma. Awake resection was proposed. During the cortical mapping, counting and naming task combined with right upper limb movement enabled the identification of the ventral premotor cortex and negative motors areas. The so-called Broca's area was not eloquent. Subpial dissection was performed by avoiding coagulation until the inferior fronto-occipital fasciculus and the junction between the output projection fibers and the anterior part of the superior longitudinal fasciculus III were reached. The patient resumed a normal familial and socio-professional life despite the resection of Broca's area. The video can be found here: https://youtu.be/OALk0tvctQw .
Related Concept Videos
Graded Potential
Graded potentials fall into two categories: depolarizing and hyperpolarizing. Depolarizing graded potentials typically occur when sodium (Na+) or...
Types of Aggregate Grading
Well-graded aggregates include a complete range of necessary size fractions that fit together to create a dense matrix with minimal voids, represented by a smooth, continuous gradation curve. This type of grading ensures good...
Sieve Analysis and Grading Curves
Microtubule Associated Proteins (MAPs)
Plotting of Topographic Maps
Coordinates and Map Projections

