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Prevalence of Congenital Heart Disease at Live Birth in China

Qu-Ming Zhao1, Fang Liu1, Lin Wu1

  • 1Pediatric Heart Center, Children's Hospital of Fudan University, Shanghai, China.

The Journal of Pediatrics
|October 2, 2018
PubMed

Insights

This study found a congenital heart disease (CHD) prevalence of 8.98 per 1000 live births in China. Female infants had higher overall CHD rates, while males had more critical forms.

Area of Science:

  • Pediatrics
  • Cardiology
  • Public Health

Background:

  • Congenital heart disease (CHD) is a significant global health concern.
  • Accurate prevalence data is crucial for resource allocation and intervention strategies in China.

Purpose of the Study:

  • To determine the prevalence of congenital heart disease (CHD) in a large cohort of Chinese infants.
  • To identify demographic and clinical risk factors associated with CHD in China.

Main Methods:

  • Prospective, multicenter screening of 122,765 infants across 18 Chinese hospitals.
  • Diagnosis confirmed via echocardiography, clinical assessment, and follow-up.
  • Data collected between August 2011 and November 2012.

Main Results:

  • Overall CHD prevalence was 8.98 per 1000 live births.
  • Ventricular septal defect was the most common type (3.3 per 1000).
  • Female infants showed higher prevalence for overall and mild CHD; males had higher critical CHD rates. Risk factors included preterm birth, low birth weight, advanced maternal age, and family history.

Conclusions:

  • The study provides comprehensive CHD prevalence data for China, comparable to Western estimates.
  • Findings highlight the need for targeted screening and interventions for high-risk groups.
  • This research offers valuable insights for public health policy and clinical practice in China.
Abstract

Keywords:
congenital heart diseasenewborn screeningprevalence

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