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Updated: Feb 4, 2026

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
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In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

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Myocardial perfusion assessed with cardiac computed tomography in women without coronary heart disease

Daria Frestad Bechsgaard1, Ida Gustafsson1, Jesper James Linde2

  • 1Department of Cardiology, Hvidovre University Hospital, University of Copenhagen, Copenhagen, Denmark.

Clinical Physiology and Functional Imaging
|October 2, 2018
PubMed

Insights

This study describes normal myocardial perfusion patterns in healthy women using CT perfusion imaging. It establishes baseline values for assessing coronary artery disease risk.

Area of Science:

  • Cardiovascular imaging
  • Radiology
  • Medical diagnostics

Background:

  • Coronary artery disease (CAD) diagnosis relies on assessing myocardial ischemia.
  • Coronary CT angiography and CT perfusion (CTP) offer a non-invasive method for evaluating CAD.
  • Normal myocardial perfusion patterns in asymptomatic individuals require further characterization.

Purpose of the Study:

  • To investigate global and regional myocardial perfusion at rest and during hyperemia in asymptomatic women without coronary heart disease.
  • To establish normal reference values for myocardial perfusion reserve (MPR) and transmural perfusion ratio (TPR) using static CTP.
  • To describe the distribution of myocardial perfusion in the left ventricular myocardium.

Main Methods:

  • A 320-row CT scanner with a static protocol was used for semi-quantitative assessment of rest and stress CTP.
  • 34 asymptomatic middle-aged women without obstructive CAD or history of coronary heart disease were included.
  • A 16-segment model was utilized to assess global and regional MPR and TPR.

Main Results:

  • Resting and hyperemic myocardial perfusion showed heterogeneous distribution throughout the left ventricular myocardium.
  • Global MPR increased by 158% during hyperemia, with the highest increase in the right coronary artery territory.
  • No significant differences in perfusion parameters were observed based on epicardial artery status, age, or menopausal status.

Conclusions:

  • This study provides descriptive data on global and regional myocardial perfusion in healthy middle-aged women.
  • The findings contribute to understanding normal myocardial perfusion patterns for improved CAD assessment.
  • CTP is a valuable tool for non-invasive evaluation of myocardial perfusion.
Abstract

Keywords:
CT perfusionmyocardial perfusion reservenon-invasive imagingreference populationstress testingtransmural perfusion ratio

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