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The oncogenic roles of nuclear receptor coactivator 1 in human esophageal carcinoma

Lu Wang1,2, Weiwei Li2, Kai Li2

  • 1Department of Immunotherapy and Gastrointestinal Oncology, Affiliated Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China.

Cancer Medicine
|October 2, 2018
PubMed

Insights

Nuclear receptor coactivator 1 (NCOA1) is elevated in esophageal squamous cell carcinoma (ESCC), correlating with aggressive disease and poor survival. NCOA1 inhibition reduces ESCC cell growth and spread, suggesting it as a prognostic biomarker and therapeutic target.

Area of Science:

  • Molecular biology
  • Oncology
  • Gene regulation

Background:

  • Nuclear receptor coactivator 1 (NCOA1) regulates gene expression via steroid receptors like AR, ERα, and ERβ.
  • NCOA1 dysregulation is implicated in various cancers, but its role in esophageal squamous cell carcinoma (ESCC) is unclear.

Purpose of the Study:

  • To investigate the clinical relevance and functional roles of NCOA1 in human ESCC.
  • To determine if NCOA1 levels can serve as a prognostic biomarker for ESCC patients.

Main Methods:

  • Analysis of NCOA1 protein, mRNA levels, and gene amplification in ESCC tissues.
  • Correlation of NCOA1 levels with clinic-pathologic parameters and patient survival.
  • In vitro experiments involving NCOA1 gene silencing in ESCC cells to assess effects on proliferation, migration, and invasion.

Main Results:

  • Elevated NCOA1 protein/mRNA and gene amplification were observed in human ESCC.
  • Higher NCOA1 levels correlated with more aggressive clinic-pathologic features and poorer overall survival.
  • NCOA1 silencing significantly reduced ESCC cell proliferation, migration, and invasion.

Conclusions:

  • NCOA1 plays a significant role in the progression of human ESCC.
  • NCOA1 levels are a potential independent prognostic biomarker for ESCC survival.
  • Targeting NCOA1 represents a promising therapeutic strategy for ESCC treatment.
Keywords:
SRC-1coregulatoresophageal carcinomainvasivenessmigrationproliferationsex steroid receptor signaling

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