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Impact of Fabrication Techniques and Polishing Procedures on Surface Roughness of Denture Base Resins
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Combinatorial Surface Roughness Effects on Osteoclastogenesis and Osteogenesis.

Yang Zhang1, S Elisa Chen1,2, Jinlong Shao1

  • 1Department of Biomaterials , Radboudumc , Nijmegen 6525 GA , The Netherlands.

ACS Applied Materials & Interfaces
|October 2, 2018
PubMed
Summary
This summary is machine-generated.

Implant surface roughness influences osteoclast behavior and their stimulation of bone growth. Tailoring roughness can optimize metallic implants for better osseointegration by controlling bone cell interactions.

Keywords:
coupling of bone resorption and formationosteoclastsosteogenic differentiationsubtypesurface roughness

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Area of Science:

  • Biomaterials Science
  • Cell Biology
  • Orthopedic Research

Background:

  • Implant surface properties critically influence bone healing and osseointegration.
  • Osteoclasts play a significant role in bone regeneration, impacting implant success.

Purpose of the Study:

  • To investigate how varying surface roughness of titanium implants affects osteoclast differentiation and function.
  • To determine the extent to which these osteoclasts stimulate osteogenic differentiation of osteoprogenitor cells.

Main Methods:

  • Osteoclasts were induced from RAW264.7 cells and primary mouse macrophages on titanium surfaces with controlled roughness (Ra 0.02–3.63 μm).
  • Osteoclast phenotype (number, morphology, differentiation markers) and their anabolic effects on osteoblastic cells were analyzed.
  • The clastokine CTHRC1 was identified as a mediator of osteoclast-induced osteogenic differentiation.

Main Results:

  • Different surface roughness levels induced distinct osteoclast phenotypes with varying morphologies and features.
  • Osteoclast phenotypes exhibited differential stimulatory effects on osteogenic differentiation of osteoblastic cells.
  • Osteoclast potency to enhance osteogenesis correlated logarithmically with the number of nuclei per osteoclast.

Conclusions:

  • Surface roughness, osteoclastogenesis, and osteogenic differentiation are interconnected processes.
  • Tailoring implant surface roughness offers a strategy to locally regulate osseointegration by coupling osteoclast and osteoblast activity.