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Warfarin-related Nephropathy.

Anvesh Golla1, R Goli1, V K Nagalla1

  • 1Department of Nephrology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India.

Indian Journal of Nephrology
|October 2, 2018
PubMed
Summary
This summary is machine-generated.

Anticoagulant-related nephropathy (ACRN) is acute kidney injury from excessive warfarin. Prompt diagnosis and steroid treatment can restore kidney function in patients on long-term anticoagulation.

Keywords:
Acute kidney injuryanticoagulant-related nephropathycorticosteroidsmitral valve replacementwarfarin

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Area of Science:

  • Nephrology
  • Cardiology
  • Pharmacology

Background:

  • Warfarin-related nephropathy (ACRN) is a form of acute kidney injury (AKI) linked to excessive anticoagulation.
  • While histologically defined, the clinical management of ACRN in patients needing lifelong anticoagulation is poorly documented.

Observation:

  • A 50-year-old Indian woman on long-term warfarin post-mitral valve replacement presented with AKI.
  • Renal biopsy findings were consistent with ACRN.
  • She received steroid treatment, leading to normalization of creatinine levels within two weeks.

Findings:

  • A presumptive diagnosis of ACRN requires evidence of severe warfarin coagulopathy and exclusion of other AKI causes in patients on chronic anticoagulation.
  • Regular renal function monitoring is crucial for patients undergoing anticoagulant therapy.

Implications:

  • This case highlights the potential efficacy of steroids in managing ACRN.
  • Emphasizes the importance of considering ACRN in patients with AKI on anticoagulation.
  • Underscores the need for vigilant renal function monitoring in this patient population.