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Updated: Feb 4, 2026

An Efficient Method for Adenovirus Production
Published on: June 10, 2021
Adenovirus Interstitial Nephritis: An Unusual Cause for Early Graft Dysfunction
1Department of Nephrology, G. Kuppuswamy Naidu Memorial Hospital, Coimbatore, Tamil Nadu, India.
Abstract:
We describe a rare case of adenovirus interstitial nephritis in a 37-year-old man, 4 weeks following deceased donor renal transplantation. He presented with gross hematuria and acute graft dysfunction. A renal biopsy revealed necrotizing tubulointerstitial nephritis with intranuclear viral inclusions in the tubular epithelial cells. Immunohistochemistry and polymerase chain reaction confirmed adenovirus infection. Reduction in immunosuppression alone resulted in rapid improvement of graft function. Awareness of the clinical and characteristic biopsy findings may help establish the correct diagnosis, which is crucial as disseminated infection, if left untreated, is associated with a high mortality rate in renal allograft recipients.
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