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Updated: Feb 4, 2026

Cell-based Assay Protocol for the Prognostic Prediction of Idiopathic Scoliosis Using Cellular Dielectric Spectroscopy
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Intraspinal Anomalies in Early Onset Scoliosis: Current Concepts

Manoj Singrakhia1, Nikhil Malewar1, Ajit Jangle1

  • 1Spine Surgery Department, Shanta Spine Institute, Nagpur, Maharashtra, India.

Journal of Pediatric Neurosciences
|October 2, 2018
PubMed

Insights

Early onset scoliosis (EOS) in children under 5 poses risks to lung development. Identifying neurogenic causes via MRI is crucial for effective treatment and preventing neurological complications.

Area of Science:

  • Pediatric Orthopedics
  • Pediatric Neurology
  • Medical Imaging

Background:

  • Early onset scoliosis (EOS) affects children under 5 years.
  • EOS can impede thoracic cage development and pulmonary maturation.
  • Accurate etiological diagnosis (congenital, neurogenic, idiopathic, syndromic) is essential.

Purpose of the Study:

  • To highlight the importance of evaluating spinal cord anomalies in EOS.
  • To emphasize the role of advanced imaging in diagnosing neurogenic EOS.
  • To underscore the risks associated with untreated spinal abnormalities during scoliosis correction.

Main Methods:

  • Review of current diagnostic approaches for EOS.
  • Emphasis on the diagnostic utility of Magnetic Resonance Imaging (MRI).
  • Analysis of potential complications arising from unaddressed spinal cord issues.

Main Results:

  • Increased awareness of neurogenic causes for EOS due to MRI advancements.
  • Demonstration of the critical link between spinal cord anomalies and EOS.
  • Identification of potential neurological complications from interventions without addressing underlying spinal issues.

Conclusions:

  • Early diagnosis and treatment of spinal cord anomalies are vital for managing EOS.
  • MRI plays a key role in identifying neurogenic etiologies of EOS.
  • Failure to treat spinal cord anomalies before scoliosis intervention can lead to severe neurological deficits.

Keywords:
Early onset scoliosisintraspinal anomaliesthoracic insufficiency syndrome

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