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Compound Fuling Granule Suppresses Ovarian Cancer Development and Progression by disrupting mitochondrial function,

Shanming Ruan1, Zhiqian Zhang2,3, Xinxin Tian2,4

  • 1Department of Medical Oncology, First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310003, Zhejiang, China.

Journal of Cancer
|October 2, 2018
PubMed

Insights

Compound Fuling Granule (CFG) suppresses ovarian cancer progression by disrupting mitochondrial function and altering key metabolic pathways like galactose and fatty acid metabolism. This traditional Chinese medicine shows promise in inhibiting tumor growth and metastasis.

Area of Science:

  • Oncology
  • Pharmacology
  • Metabolomics

Background:

  • Compound Fuling Granule (CFG), a traditional Chinese medicine, has shown potential in suppressing ovarian cancer.
  • The precise mechanisms by which CFG exerts its anti-cancer effects require further elucidation.

Purpose of the Study:

  • To investigate the underlying mechanisms of CFG in inhibiting ovarian cancer cell growth, migration, and metastasis.
  • To explore the systemic effects of CFG on ovarian cancer progression using metabolomics and transcriptomics.

Main Methods:

  • Ovarian SKOV3 cancer cells were treated with CFG to assess mitochondrial function (fragmentation, membrane potential, cytochrome c release).
  • Two in vivo mouse models (subcutaneous and tail intravenous injection) were established to evaluate CFG's effect on tumor growth and metastasis.
  • Gas chromatography-mass spectrometry (GC-MS) was used for metabolomic profiling of plasma samples.
  • Integrative analysis of metabolomics and transcriptomics data was performed.

Main Results:

  • CFG induced mitochondrial fragmentation, reduced mitochondrial membrane potential, and promoted cytochrome c release in ovarian cancer cells.
  • In vivo administration of CFG suppressed both in situ tumor growth and lung metastasis.
  • Metabolomic analysis identified significant alterations in 26 metabolites (12 pathways) in the subcutaneous model and 19 metabolites (7 pathways) in the intravenous model.
  • Integrative analysis linked these metabolic changes to galactose and fatty acid metabolism.

Conclusions:

  • CFG suppresses ovarian cancer progression by impacting mitochondrial function and energy metabolism.
  • CFG may exert its anti-cancer effects through the regulation of galactose and fatty acid metabolic pathways.
  • These findings highlight CFG as a potential therapeutic agent for ovarian cancer, warranting further investigation into its mitochondrion-related metabolic regulatory mechanisms.
Keywords:
Compound fuling granuleFatty acid metabolismGalactose metabolismMitochondrionOvarian cancer

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