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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

274
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
274
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

238
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
238
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

261
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
261
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

217
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
217
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

255
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
255
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

701
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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Related Experiment Video

Updated: Feb 4, 2026

Kinematics and Ground Reaction Force Determination: A Demonstration Quantifying Locomotor Abilities of Young Adult, Middle-aged, and Geriatric Rats
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The Top Articles in Geriatrics 2016-2017.

Kenneth Lam1, Dov Gandell1

  • 1Department of Medicine, Division of Geriatrics, University of Toronto, Toronto, ON, Canada.

Canadian Geriatrics Journal : CGJ
|October 2, 2018
PubMed
Summary

This review highlights key advances in geriatric medicine, focusing on dementia diagnosis, risk factors, and interventions for older adults. It covers critical updates in cognitive assessment and treatment strategies for inpatients.

Keywords:
2017comprehensive geriatric assessmentdeliriumdementiageriatricshyperlipidemiahypertensioninpatient mobilizationliterature update

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Area of Science:

  • Geriatric Medicine
  • Neurology
  • Internal Medicine

Background:

  • Geriatric medicine is rapidly evolving with new research impacting clinical practice.
  • Understanding recent advancements is crucial for optimal care of older adults.

Purpose of the Study:

  • To summarize the top 11 impactful articles in geriatric medicine from the past two years.
  • To provide an overview of significant findings across various subspecialties.

Main Methods:

  • Systematic review of high-impact publications in geriatric medicine.
  • Selection based on relevance and clinical significance.

Main Results:

  • Key findings include updated diagnostic criteria for Lewy Body dementia.
  • Advances in Alzheimer's disease biomarker diagnosis are discussed.
  • Optimal cutoff for Montreal Cognitive Assessment (MoCA) is examined.
  • Evidence on antipsychotics for delirium prevention is reviewed.
  • Benefits of inpatient mobilization and intensive blood pressure management are highlighted.
  • Statin therapy for primary prevention in older adults is assessed.
  • Role of comprehensive geriatric assessment in surgery and oncology is explored.

Conclusions:

  • These top articles offer critical updates for geriatric care.
  • The findings emphasize the importance of early diagnosis and tailored interventions.
  • Geriatric assessment remains vital across diverse clinical settings.