Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

2.0K
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
2.0K
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

3.0K
The pathophysiology of pneumonia involves the following steps:
3.0K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

3.6K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.6K
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

957
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
957
Pathophysiology of Vomiting01:22

Pathophysiology of Vomiting

3.1K
Vomiting is a complex physiological response to expel harmful or irritating substances from the body. It's a defensive mechanism triggered by stimuli like poisons, microbial toxins, cytotoxic drugs, and mechanical abdominal distension. The process is centrally coordinated by the vomiting (or emetic) center located in the medulla of the brainstem. This area, rich in muscarinic M1, histamine H1, neurokinin 1 (NK1), and serotonin 5-HT3 receptors, coordinates the act of vomiting through...
3.1K
Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

1.3K
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Differential Effects of Calcium Alginate and Carboxymethylcellulose Wound Dressing Extracts on Human Sensory Neuron Regeneration and Secretome.

Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society·2026
Same author

Improvement of Charcot-Marie-Tooth Phenotype with a Nanocomplex Treatment in Two Transgenic Models of CMT1A.

Biomaterials research·2024
Same author

Specific Features of Stromal Cells Isolated from the Two Layers of Subcutaneous Adipose Tissue: Roles of Their Secretion on Angiogenesis and Neurogenesis.

Journal of clinical medicine·2023
Same author

Blockade of Cholecystokinin Type 2 Receptors Prevents the Onset of Vincristine-Induced Neuropathy in Mice.

Pharmaceutics·2022
Same author

Charcot-Marie-Tooth-1A and sciatic nerve crush rat models: insights from proteomics.

Neural regeneration research·2022
Same author

Arundinosides I-IX and graminifolosides A-B: 2R-benzylmalate and 2R-isobutylmalates derivatives from Arundina graminifolia (D.Don) Hochr. with antioxidant, cytocompatibility and cytoprotective properties.

Phytochemistry·2022

Related Experiment Video

Updated: Feb 4, 2026

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

1.5K

Glycation Damage: A Possible Hub for Major Pathophysiological Disorders and Aging.

Maxime Fournet1, Frédéric Bonté2, Alexis Desmoulière3

  • 11University of Limoges, Faculty of Pharmacy, Department of Physiology, EA 6309, F-87025 Limoges, France.

Aging and Disease
|October 2, 2018
PubMed
Summary
This summary is machine-generated.

Glycation, a process affecting proteins, nucleic acids, and lipids, can lead to harmful advanced glycation end products (AGEs). Accumulation of AGEs contributes to aging and various diseases when natural defenses fail.

Keywords:
advanced glycation end productagingdiabetesendogenous glycationexogenous glycationneurodegenerative disorders

More Related Videos

Advanced Glycation End-Products Sensitize Human Sensory-Like Neuron Cells to Capsaicin-Induced Calcium Influx
06:05

Advanced Glycation End-Products Sensitize Human Sensory-Like Neuron Cells to Capsaicin-Induced Calcium Influx

Published on: May 2, 2025

1.0K
Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment
05:19

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment

Published on: July 7, 2023

3.4K

Related Experiment Videos

Last Updated: Feb 4, 2026

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

1.5K
Advanced Glycation End-Products Sensitize Human Sensory-Like Neuron Cells to Capsaicin-Induced Calcium Influx
06:05

Advanced Glycation End-Products Sensitize Human Sensory-Like Neuron Cells to Capsaicin-Induced Calcium Influx

Published on: May 2, 2025

1.0K
Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment
05:19

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment

Published on: July 7, 2023

3.4K

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pathology

Background:

  • Glycation is a physiological and pathological process involving proteins, nucleic acids, and lipids.
  • It leads to the formation of advanced glycation end products (AGEs) through non-enzymatic reactions.
  • AGE accumulation is influenced by factors like oxidative stress, UV exposure, and nutrition.

Purpose of the Study:

  • To elucidate the mechanisms and consequences of glycation and AGE formation.
  • To understand the role of glycation in various pathologies.
  • To highlight the balance between glycation damage and cellular defense mechanisms.

Main Methods:

  • Review of biochemical pathways of glycation.
  • Analysis of cellular and molecular consequences of AGE formation.
  • Examination of endogenous anti-glycation defense systems.

Main Results:

  • Glycation alters protein structure and function, damages DNA, and compromises cell membranes.
  • Mitochondrial bioenergy production can be impaired by glycation.
  • Failure of defense mechanisms like proteasomal degradation and DNA repair leads to AGE accumulation.

Conclusions:

  • AGEs are implicated in aging and numerous diseases, including diabetes, neurodegenerative disorders, atherosclerosis, and cancer.
  • Understanding glycation pathways is crucial for developing therapeutic strategies against age-related and metabolic diseases.
  • Maintaining cellular defense mechanisms is vital for preventing glycation-induced pathology.