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Understanding Lignin Aggregation Processes. A Case Study: Budesonide Entrapment and Stimuli Controlled Release from
Mika H Sipponen1,2, Heiko Lange1, Mariko Ago2
1Department of Chemical Science and Technologies, University of Rome Tor Vergata, Via della Ricerca Scientifica, Rome 00133, Italy.
ACS Sustainable Chemistry & Engineering
|October 2, 2018
Summary
Researchers elucidated lignin nanoparticle (LNP) formation, revealing a nucleation-growth mechanism. This understanding enabled budesonide entrapment in LNPs for controlled intestinal drug delivery.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Pharmaceutical Sciences
Background:
- Lignin nanoparticles (LNPs) offer potential for drug delivery systems.
- Understanding the self-assembly mechanism of LNPs is crucial for controlling their properties.
- Budesonide, a corticosteroid, requires effective delivery systems for treating inflammatory conditions.
Purpose of the Study:
- To elucidate the mechanism of lignin nanoprecipitation and self-assembly.
- To demonstrate the entrapment of budesonide within LNPs.
- To investigate the controlled release of budesonide from LNPs.
Main Methods:
- Studied lignin nanoparticle generation from aqueous ethanol solutions.
- Investigated the nucleation-growth mechanism of LNP formation.
- Demonstrated budesonide entrapment and characterized its release kinetics.
Main Results:
- LNP formation follows a kinetically controlled nucleation-growth mechanism.
- Large lignin molecules act as critical nuclei in LNP formation.
- Achieved successful budesonide entrapment and demonstrated pH-triggered and surfactant-responsive release.
Conclusions:
- The study provides fundamental mechanistic insights into LNP formation and self-assembly.
- Developed a promising intestinal delivery system for budesonide using engineered LNPs.
- Demonstrated the potential for controlled size and release properties of actives entrapped in LNPs.
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