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Relationship between Extension or Texture Features of Late Gadolinium Enhancement and Ventricular Tachyarrhythmias in

Yasuo Amano1, Yasuyuki Suzuki2, Fumi Yanagisawa1

  • 1Department of Radiology, Nihon University Hospital, 1-6 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-8309, Japan.

Biomed Research International
|October 2, 2018
PubMed

Insights

Patients with hypertrophic cardiomyopathy (HCM) and ventricular tachyarrhythmias show wider late gadolinium enhancement (LGE) extension. LGE extension and texture analysis can help identify arrhythmia risk in HCM patients.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Cardiac Electrophysiology

Background:

  • Hypertrophic cardiomyopathy (HCM) is a genetic heart disease associated with increased risk of sudden cardiac death.
  • Ventricular tachyarrhythmias are a major cause of mortality in HCM patients.
  • Late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (CMR) is a marker of myocardial scarring in HCM.

Purpose of the Study:

  • To investigate the association between the extent and texture characteristics of LGE and the occurrence of ventricular tachyarrhythmias in patients with HCM.
  • To determine if LGE features can predict ventricular tachyarrhythmias in HCM.

Main Methods:

  • Retrospective analysis of CMR scans from 23 HCM patients.
  • Quantification of LGE extension using the American Heart Association segments model.
  • Texture analysis of myocardial LGE using MaZda software.
  • Statistical evaluation including unpaired t-test and receiver-operating characteristic (ROC) analysis.

Main Results:

  • Patients with ventricular tachyarrhythmias had significantly more LGE segments compared to those without (p < 0.01).
  • Entropy of LGE (texture feature) was lower in patients with arrhythmias (p < 0.01, AUC = 0.72).
  • The number of LGE segments demonstrated a higher predictive value for identifying patients with ventricular tachyarrhythmias (AUC = 0.96) than LGE texture analysis.

Conclusions:

  • Wider extension of LGE is associated with a history of ventricular tachyarrhythmias in HCM.
  • LGE extension is a stronger predictor of ventricular tachyarrhythmias in HCM than LGE texture features.
  • LGE assessment, particularly its extension, is valuable for risk stratification of ventricular tachyarrhythmias in HCM.
Abstract

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