Related Experiment Video
Updated: Feb 4, 2026
06:14
Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model
Published on: February 17, 2023
5.1K
Effects of Curcumin on Alveolar Bone Loss in Experimental Periodontitis in Rats: A Morphometric and Histopathologic
Aysun Akpinar1, Metin Calisir1, Nebi Cansın Karakan1
11 Cumhuriyet University, Faculty Of Dentistry Periodontology Department, Sivas, Turkey.
Summary
Systemic curcumin therapy effectively reduced alveolar bone loss in a rat model of periodontal disease. Curcumin demonstrated antioxidant and anti-inflammatory effects, mitigating bone loss and promoting osteoblast activity.
Area of Science:
- Periodontology
- Pharmacology
- Biochemistry
Background:
- Curcumin, derived from turmeric rhizomes, possesses known antioxidant and anti-inflammatory properties.
- Periodontitis is characterized by inflammation and alveolar bone loss.
- Systemic administration of natural compounds is being explored for therapeutic benefits.
Purpose of the Study:
- To investigate the efficacy of systemic curcumin therapy in mitigating alveolar bone loss.
- To evaluate the impact of curcumin on inflammatory markers and bone cell activity in experimental periodontitis.
Main Methods:
- A ligature-induced periodontitis model was established in Wistar rats.
- Rats received daily oral administration of curcumin at 75 mg/kg (C75) or 150 mg/kg (C150), or served as controls.
- Histopathological examination, alveolar bone loss measurement, and analysis of Interleukin-1β (IL-1β) and Interleukin-10 (IL-10) levels were performed.
Main Results:
- Curcumin treatment (C75 and C150) significantly reduced alveolar bone loss compared to the ligated control group.
- IL-1β levels were significantly lower in curcumin-treated groups, particularly in gingival homogenates.
- Curcumin administration increased osteoblast numbers and decreased osteoclast numbers, indicating a shift towards bone formation.
Conclusions:
- Systemic curcumin administration effectively reduces ligature-induced alveolar bone loss in rats.
- Curcumin's anti-inflammatory and bone-protective effects are dose-dependent.
- Curcumin shows potential as a therapeutic agent for periodontal disease management.
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