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Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development

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Alkyl Sulfinates: Radical Precursors Enabling Drug Discovery.

Joel M Smith¹, Janice A Dixon¹, Justine N deGruyter¹

¹Department of Chemistry , The Scripps Research Institute , 10550 North Torrey Pines Road , La Jolla , California 93037 , United States.

Journal of Medicinal Chemistry

|October 2, 2018

Summary

Sulfinates, now called Diversinates, are rapidly adopted in drug discovery for reaction validation. This review highlights over 50 compelling recent examples to identify predictable reactivity trends.

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Area of Science:

Medicinal Chemistry
Organic Synthesis
Drug Discovery

Background:

Modern drug discovery necessitates rigorous validation of new chemical reactions.
Sulfinates, marketed as Diversinates, have gained significant traction in medicinal chemistry.
Numerous patents and primary reports demonstrate their increasing use.

Purpose of the Study:

To review compelling applications of sulfinates in medicinal chemistry over the past five years.
To identify robust and predictable trends in sulfinate reactivity.
To aid in the validation process for new drug discovery reactions.

Main Methods:

Comprehensive literature search of primary reports and patents.
Analysis of over 50 published examples of sulfinate reactions.
Identification and categorization of reactivity patterns and trends.

Main Results:

Demonstrated alacritous adoption of sulfinates by the medicinal chemistry community.
Highlighted over 50 compelling use cases from the last five years.
Identified key trends in sulfinate reactivity, supporting their predictability.

Conclusions:

Sulfinates (Diversinates) are a validated and increasingly utilized tool in drug discovery.
The reviewed examples provide a foundation for understanding and predicting sulfinate reactivity.
This work supports the rigorous validation required for implementing new reactions in drug development.