Alkyl Sulfinates: Radical Precursors Enabling Drug Discovery

Area of Science:

• Medicinal Chemistry
• Organic Synthesis
• Drug Discovery

Background:

• Modern drug discovery necessitates rigorous validation of new chemical reactions.
• Sulfinates, marketed as Diversinates, have gained significant traction in medicinal chemistry.
• Numerous patents and primary reports demonstrate their increasing use.

Purpose of the Study:

• To review compelling applications of sulfinates in medicinal chemistry over the past five years.
• To identify robust and predictable trends in sulfinate reactivity.
• To aid in the validation process for new drug discovery reactions.

Main Methods:

• Comprehensive literature search of primary reports and patents.
• Analysis of over 50 published examples of sulfinate reactions.
• Identification and categorization of reactivity patterns and trends.

Main Results:

• Demonstrated alacritous adoption of sulfinates by the medicinal chemistry community.
• Highlighted over 50 compelling use cases from the last five years.
• Identified key trends in sulfinate reactivity, supporting their predictability.

Conclusions:

• Sulfinates (Diversinates) are a validated and increasingly utilized tool in drug discovery.
• The reviewed examples provide a foundation for understanding and predicting sulfinate reactivity.
• This work supports the rigorous validation required for implementing new reactions in drug development.