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    Area of Science:

    • Medical image analysis
    • Deep learning
    • Computational pathology

    Background:

    • Limited annotated data is a major challenge for deep learning (DL) in medical image analysis.
    • Collecting high-quality annotations is time-consuming, costly, and requires domain expertise.
    • This hinders the development of large-scale medical imaging databases.

    Purpose of the Study:

    • To address the challenge of limited annotated data in medical image analysis.
    • To develop novel methods for training DL models using crowdsourced and less domain-specific data.
    • To improve the efficiency and accessibility of medical image annotation for DL.

    Main Methods:

    • Introduced a robust aggregation layer for convolutional neural networks to handle noisy crowdsourced annotations [S5].
    • Developed a method to translate biomedical images into star-shaped objects embeddable in game canvases, reducing annotation domain knowledge requirements [S6].
    • Validated methods on breast cancer histology images and compared performance against baseline approaches.

    Main Results:

    • The robust aggregation method showed significant improvements over majority voting for noisy annotations.
    • The image-to-game object translation technique demonstrated promising results compared to conventional crowdsourcing.
    • Both methods effectively reduced the reliance on extensive domain expertise for data annotation.

    Conclusions:

    • Novel DL approaches can effectively utilize noisy crowdsourced data for medical image analysis.
    • Transforming images into game-like objects offers a promising alternative to traditional annotation methods.
    • These advancements facilitate the development of DL models with less annotated data and reduced expert input.