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Urinary Retention Associated With Cariprazine: A Case Report
Leonid Kapulsky1, Benjamin D Brody
1New York-Presbyterian Hospital, Weill Cornell Medical Center, New York, NY.
Clinical Neuropharmacology
|October 2, 2018
Summary
Urinary retention is a rare side effect of antipsychotics. This case study reports urinary retention associated with cariprazine, a novel antipsychotic, prompting further investigation into its mechanisms.
Area of Science:
- Pharmacology
- Neuroscience
- Urology
Background:
- Urinary retention is a known adverse effect of antipsychotic medications, often linked to anticholinergic and adrenergic pathways.
- While documented with various antipsychotics, this effect has not been previously reported with cariprazine.
Observation:
- A case of acute urinary retention occurred in a patient treated with cariprazine.
- The patient experienced symptoms consistent with bladder outlet obstruction.
Findings:
- This report details the first known instance of urinary retention associated with cariprazine use.
- The precise mechanism underlying cariprazine-induced urinary retention requires further elucidation.
Implications:
- Clinicians should be aware of the potential for cariprazine to cause urinary retention, despite its novel profile.
- Further research is needed to understand the neurochemical and physiological basis of this adverse event and inform patient management.
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