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[Filamentous fungal infection in burned patients: retrospective study.]
Florencia Spesso1, Susana Aiassa, Alicia Garutti
1Hospital Córdoba. florenciaspesso@yahoo.com.ar.
Introduction:
Infections are the most frequent complications in burn patients. Filamentous fungi have an uncertain place within the statistics, since in our media data regarding their prevalence, causal agents and outcome of those who suffer them remain scarce. The aim of this study was to evaluate the prevalence of fungal infection by filamentous fungi (IHF) in patients hospitalized in burn intensive care unit (BICU), and to review clinical, epidemiological, microbiological and evolutionary characteristics of these patients and to know the frequency and distribution of the isolated fungi.
Materials And Methods:
Retrospective and descriptive study. It includes all individuals admitted in burns intensive care unit (2012-2015), with positive culture for filamentous fungi in skin biopsies and bedsores.
Results:
A total of 168 patients were admitted in the BICU in a period of 3 years. 90% were major burned and 17% of them developed IHF (29/168). Aspergillus spp (24%), Fusarium sp (14%), Mucor spp (3%) and various black fungus genera (58%) were the main genera found in cultives. About 24% of the patients with IHF died and Fusarium spp was found in 50% of the cases. The cause of death was irreversible cardiogenic shock with multiorgan failure.
Conclusions:
Filamentous fungal infection was present in 17% of burned patients. The main isolatte fungi in samples were dematiaceous mould. Mortality among patients was 24%, with Fusarium being the fungus found in the highest number of deaths (50%).
Insights
Filamentous fungal infections affected 17% of burn patients, with dematiaceous molds being most common. Fusarium species were linked to 50% of deaths in this burn intensive care unit (BICU) study.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Burn Care
Background:
- Infections are a major complication for burn patients.
- Data on filamentous fungal infections (IHF) in burn survivors is limited.
- Understanding IHF prevalence and characteristics is crucial for patient outcomes.
Purpose of the Study:
- To determine the prevalence of IHF in burn intensive care unit (BICU) patients.
- To analyze the clinical, epidemiological, and microbiological features of IHF.
- To identify the frequency and distribution of isolated fungi.
Main Methods:
- Retrospective and descriptive study design.
- Inclusion of patients admitted to the BICU from 2012-2015.
- Analysis of positive cultures for filamentous fungi from skin biopsies and bedsores.
Main Results:
- 17% (29/168) of BICU patients developed IHF.
- Aspergillus spp. (24%), Fusarium sp. (14%), and black fungus genera (58%) were predominant.
- Mortality rate for IHF patients was 24%, with Fusarium implicated in 50% of deaths.
Conclusions:
- Filamentous fungal infections occur in 17% of burn patients.
- Dematiaceous molds are the primary isolates.
- Fusarium species are associated with a significant proportion of mortality.
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