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Updated: Feb 4, 2026

Preparation and Photoacoustic Analysis of Cellular Vehicles Containing Gold Nanorods
Published on: May 2, 2016
Internalization capabilities of gold-198 nanoparticles: Comparative evaluation of effects of chitosan agent on
Mohammad Reza Aboudzadeh Rovais1, Behrouz Alirezapour1, Mohammad Esmaeil Moassesi1
1Radiation Application Research School, Nuclear Science and Technology Research Institute, P.O. Box 14395-836, Tehran, Iran.
Abstract:
In this study, internalization of positively charged chitosan-coated nanoparticles (198AuNPs@chitosan) on MCF-7 cells was investigated by γ-ray spectroscopy and then statistically compared to that of 198Au and negatively charged citrate-stabilized nanoparticles (198AuNPs). Sub-50 nm 198AuNPs@chitosan had a higher internalization compared to 198Au and 198AuNPs (p < 0.05). More cellular uptake of 198AuNP@chitosan means a higher dose of radioactivity to the tumor cells which, in turn, more effective treatment of the cancer.
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