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Updated: Feb 4, 2026
10:30
Use of pHluorin to Assess the Dynamics of Axon Guidance Receptors in Cell Culture and in the Chick Embryo
Published on: January 12, 2014
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Keeping up with advances in axon guidance
1Aix Marseille Univ, CNRS, IBDM, Marseille, France.
Current Opinion in Neurobiology
|October 2, 2018
Summary
Discoveries in axonal guidance reveal new molecular players and mechanisms controlling nerve growth in vertebrates. This review highlights recent advances in understanding how cells navigate the nervous system.
Area of Science:
- Neuroscience
- Molecular Biology
- Developmental Biology
Background:
- Axonal guidance is crucial for nervous system development.
- Chemotropic molecules guide growing axons.
- Understanding molecular control is key to neuroscience.
Purpose of the Study:
- To review recent advances in molecular control of axonal guidance.
- To focus on new molecular players and mechanisms.
- To explore RNA-based and trafficking roles in cue signaling.
Main Methods:
- Literature review of recent findings.
- Analysis of molecular players in vertebrate nervous systems.
- Focus on in vivo sources and locations.
Main Results:
- Identification of novel molecular players in axonal guidance.
- Elucidation of their in vivo sources and localization.
- Understanding the role of membrane trafficking and RNA mechanisms.
Conclusions:
- Significant progress has been made in understanding axonal guidance.
- New molecular players and RNA-based mechanisms are critical.
- Further research will refine our knowledge of nervous system development.
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