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TIPE Family of Proteins and Its Implications in Different Chronic Diseases
Devivasha Bordoloi1, Kishore Banik2, Bano Shabnam3
1Cancer Biology Laboratory, DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam 781039, India. devivasha@iitg.ac.in.
Abstract:
The tumor necrosis factor-α-induced protein 8-like (TIPE/TNFAIP8) family is a recently identified family of proteins that is strongly associated with the regulation of immunity and tumorigenesis. This family is comprised of four members, namely, tumor necrosis factor-α-induced protein 8 (TIPE/TNFAIP8), tumor necrosis factor-α-induced protein 8-like 1 (TIPE1/TNFAIP8L1), tumor necrosis factor-α-induced protein 8-like 2 (TIPE2/TNFAIP8L2), and tumor necrosis factor-α-induced protein 8-like 3 (TIPE3/TNFAIP8L3). Although the proteins of this family were initially described as regulators of tumorigenesis, inflammation, and cell death, they are also found to be involved in the regulation of autophagy and the transfer of lipid secondary messengers, besides contributing to immune function and homeostasis. Interestingly, despite the existence of a significant sequence homology among the four members of this family, they are involved in different biological activities and also exhibit remarkable variability of expression. Furthermore, this family of proteins is highly deregulated in different human cancers and various chronic diseases. This review summarizes the vivid role of the TIPE family of proteins and its association with various signaling cascades in diverse chronic diseases.
Insights
The tumor necrosis factor-α-induced protein 8-like (TIPE) family regulates immunity and tumorigenesis. These proteins are involved in various cellular processes and are deregulated in cancers and chronic diseases.
Area of Science:
- Molecular Biology
- Immunology
- Cell Biology
Background:
- The TIPE/TNFAIP8 family comprises four members: TIPE, TIPE1, TIPE2, and TIPE3.
- Initially recognized for roles in tumorigenesis, inflammation, and cell death, their functions extend to autophagy and lipid signaling.
Purpose of the Study:
- To review the diverse biological roles of the TIPE protein family.
- To summarize the association of TIPE proteins with signaling pathways in chronic diseases.
Main Methods:
- Literature review of studies on TIPE family proteins.
- Analysis of TIPE protein involvement in various biological processes and diseases.
Main Results:
- TIPE family proteins, despite sequence homology, exhibit distinct biological activities and expression patterns.
- These proteins are implicated in immune function, homeostasis, autophagy, and lipid metabolism.
Conclusions:
- The TIPE family plays a significant role in immune regulation and homeostasis.
- Dysregulation of TIPE proteins is linked to human cancers and various chronic diseases, highlighting their therapeutic potential.
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