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Related Experiment Video

Updated: Feb 4, 2026

Author Spotlight: Validation of SICOLE-R for Assessing Cognitive and Reading Skills in Spanish-Speaking Children and Its Role in Personalized Education
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Recent Advances in Next Generation Snakebite Antivenoms.

Cecilie Knudsen1, Andreas H Laustsen2

  • 1Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, DK-2800, Denmark. Cecilie.Knudsen@outlook.dk.

Tropical Medicine and Infectious Disease
|October 3, 2018
PubMed
Summary

Snakebite envenoming, a neglected tropical disease, spurs novel antivenom research. Advances in small molecules, aptamers, and antibody-based therapies offer new hope for effective toxin neutralization.

Keywords:
antibodiesantivenomnext generation antivenomoligonucleotidesphage displayrecombinant antivenomsmall molecule toxin inhibitorssnakebite

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Area of Science:

  • Toxicology
  • Pharmacology
  • Biotechnology

Background:

  • Snakebite envenoming is a significant global health issue, recognized as a Neglected Tropical Disease by the WHO.
  • Traditional antivenoms face challenges, necessitating the development of novel therapeutic strategies.

Purpose of the Study:

  • To review recent advances in snakebite antivenom therapies.
  • To evaluate the advantages, disadvantages, and feasibility of various toxin-neutralizing molecules.

Main Methods:

  • Exploration of small molecule inhibitors targeting enzymatic toxins.
  • Investigation of peptide- and oligonucleotide-based aptamers.
  • Development of antibody-based biotherapeutics, including recombinant polyclonal plantivenom technology.

Main Results:

  • Small molecules like varespladib, batimastat, and marimastat show potential against enzymatic toxins.
  • Aptamers and antibody-based therapies are being developed for both enzymatic and non-enzymatic toxins.
  • Novel recombinant polyclonal plantivenom technology represents a promising advancement in antibody-based antivenoms.

Conclusions:

  • Diverse technological approaches are advancing snakebite antivenom development.
  • Each therapeutic strategy offers unique benefits and challenges for toxin neutralization.
  • Continued research is crucial for improving snakebite treatment outcomes.