Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

DNA Topoisomerases02:02

DNA Topoisomerases

35.6K
Topoisomerases are enzymes that relax overwound DNA molecules during various cell processes, including DNA replication and transcription. These enzymes regulate positive and negative DNA supercoiling without changing the nucleotide sequence. DNA overwinding in a clockwise direction results in positively supercoiled DNA, whereas underwinding in a counterclockwise direction produces negatively supercoiled DNA.
Types and Mechanism of action
Topoisomerases are divided into two main types. ...
35.6K
DNA Helicases00:55

DNA Helicases

24.1K
DNA unwinding helicase enzymes are a type of motor protein. Motor proteins can translocate along filaments or polymers using energy generated from ATP hydrolysis. Helicases are involved in all the important cellular processes where DNA unwinding is required, such as DNA replication, repair, recombination, and transcription. They are present in all living organisms, but vary in their structure, function, and mechanism of action. For example, in prokaryotes, DnaB helicase binds and translocates...
24.1K
Recombinant DNA01:09

Recombinant DNA

103.2K
Overview
103.2K
DNA Replication02:40

DNA Replication

59.5K
DNA replication involves the separation of the two strands of the double helix, with each strand serving as a template from which the new complementary strand is copied.  After replication, each double-stranded DNA includes one parental or “old” strand and one “new” strand. This is known as semiconservative replication. The resulting DNA molecules have the same sequence and are divided equally into the two daughter cells.
Replication in Prokaryotes
DNA replication...
59.5K
DNA-only Transposons02:57

DNA-only Transposons

17.5K
DNA-only transposons are called autonomous transposons since they code for the enzyme transposase that is required for the transposition mechanism. Insertion of transposons can alter gene functions in multiple ways. They can mutate the gene, alter gene expression by introducing a novel promoter or insulator sequence, introduce new splice sites, and change the mRNA transcripts produced, or remodel chromatin structure.
The donor site from where the transposon is excised is either degraded or...
17.5K
DNA Packaging00:58

DNA Packaging

112.7K
Overview
112.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Stage-wise variation in serum C-reactive protein and cardiovascular risk in chronic kidney disease of uncertain etiology among Sri Lankans; a preliminary study.

BMC research notes·2026
Same author

Expanded molecular evidence of soil-transmitted helminth and Schistosoma spp. infections in Myanmar schoolchildren: A qPCR update.

PLoS neglected tropical diseases·2026
Same author

Diagnostic accuracy of nucleic acid amplification tests for human intestinal nematode infections: A systematic review and meta-analysis.

PLoS neglected tropical diseases·2026
Same author

A conceptual model for healthcare-seeking research and interventions in cutaneous leishmaniasis.

International journal for equity in health·2026
Same author

Bowel Necrosis in Leptospirosis: A Case Series of a Rare Complication.

Case reports in infectious diseases·2025
Same author

Haemoconcentration in diagnosing dengue haemorrhagic fever: evidence from a rural Sri Lankan observational study.

Transactions of the Royal Society of Tropical Medicine and Hygiene·2025

Related Experiment Video

Updated: Feb 4, 2026

Microfluidic Applications for Disposable Diagnostics
10:21

Microfluidic Applications for Disposable Diagnostics

Published on: February 3, 2008

9.3K

DNA Diagnostics for Schistosomiasis Control.

Kosala G Weerakoon1,2,3, Catherine A Gordon4, Donald P McManus5

  • 1Molecular Parasitology Laboratory, Infectious Diseases Division, QIMR Berghofer Medical Research Institute, Brisbane 4006, Australia. kosala.weerakoon@qimrberghofer.edu.au.

Tropical Medicine and Infectious Disease
|October 3, 2018
PubMed
Summary
This summary is machine-generated.

Accurate schistosomiasis diagnosis is crucial for disease control. DNA detection methods, like polymerase chain reaction (PCR), offer high sensitivity for identifying infections and aiding schistosomiasis elimination efforts.

Keywords:
DNAcontrol and eliminationdiagnosispolymerase chain reactionschistosomiasis

More Related Videos

Gene-therapy Inspired Polycation Coating for Protection of DNA Origami Nanostructures
08:30

Gene-therapy Inspired Polycation Coating for Protection of DNA Origami Nanostructures

Published on: January 19, 2019

9.7K
Author Spotlight: Engineering Molecular Tools for Disease Detection and Imaging
04:33

Author Spotlight: Engineering Molecular Tools for Disease Detection and Imaging

Published on: December 8, 2023

1.5K

Related Experiment Videos

Last Updated: Feb 4, 2026

Microfluidic Applications for Disposable Diagnostics
10:21

Microfluidic Applications for Disposable Diagnostics

Published on: February 3, 2008

9.3K
Gene-therapy Inspired Polycation Coating for Protection of DNA Origami Nanostructures
08:30

Gene-therapy Inspired Polycation Coating for Protection of DNA Origami Nanostructures

Published on: January 19, 2019

9.7K
Author Spotlight: Engineering Molecular Tools for Disease Detection and Imaging
04:33

Author Spotlight: Engineering Molecular Tools for Disease Detection and Imaging

Published on: December 8, 2023

1.5K

Area of Science:

  • Parasitology
  • Molecular Diagnostics
  • Public Health

Background:

  • Schistosomiasis remains a significant global health issue, with high disease burden.
  • Current diagnostic methods often lack the necessary sensitivity for effective case detection, especially in low-prevalence areas.
  • Inadequate diagnostics hinder control and elimination strategies by missing low-intensity infections that contribute to transmission.

Purpose of the Study:

  • To review the role and effectiveness of DNA-based diagnostic techniques in the control and elimination of schistosomiasis.
  • To highlight the advantages of DNA detection over conventional methods in specific epidemiological settings.

Main Methods:

  • Review of existing literature on diagnostic approaches for schistosomiasis.
  • Focus on DNA amplification techniques, particularly polymerase chain reaction (PCR).
  • Comparison of DNA-based methods with microscopic and serological techniques.

Main Results:

  • DNA detection methods, including PCR, demonstrate high accuracy and sensitivity.
  • These methods can detect early, pre-patent infections, which are often missed by other tests.
  • DNA diagnostics are valuable screening tools, especially in areas with reduced infection levels due to control programs.

Conclusions:

  • DNA diagnostics are essential tools for accurate schistosomiasis detection and surveillance.
  • Their high sensitivity is critical for achieving elimination goals by identifying all infectious individuals.
  • The integration of DNA-based diagnostics will significantly advance efforts towards schistosomiasis control and eradication.