When Should the Emphasis on Schistosomiasis Control Move to Elimination?
W Evan Secor1, Daniel G Colley2
1Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA. was4@cdc.gov.
Tropical Medicine and Infectious Disease
|October 3, 2018
Summary
Schistosomiasis control is shifting towards transmission elimination. However, interrupting schistosomiasis transmission requires more research and validated tools, especially in sub-Saharan Africa.
Area of Science:
- * Public Health
- * Infectious Diseases
- * Tropical Medicine
Background:
- * The World Health Organization (WHO) aims to control schistosomiasis morbidity and eliminate transmission.
- * Improvements in sanitation and water access make elimination feasible in some regions.
- * Mass drug administration remains the primary intervention in many endemic areas.
Purpose of the Study:
- * To assess the feasibility of transitioning from schistosomiasis morbidity control to transmission interruption.
- * To identify research needs for schistosomiasis elimination strategies.
- * To review current evidence and operational research on schistosomiasis control and elimination.
Main Methods:
- * Review and synthesis of numerous studies on schistosomiasis control and elimination.
- * Analysis of programmatic interventions, including mass drug administration.
- * Evaluation of the Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) findings.
Main Results:
- * Transitioning to transmission elimination is feasible in specific regions with improved infrastructure.
- * Elimination strategies are premature for most of sub-Saharan Africa without further research.
- * Current methods for breaking and validating schistosomiasis transmission are insufficient.
Conclusions:
- * Continued operational research is crucial to define infection thresholds for elimination.
- * Development and evaluation of evidence-based tools for transmission interruption and validation are needed.
- * A strategic shift towards elimination requires tailored approaches based on regional feasibility and robust research.
Related Concept Videos
Elimination Kinetics: First-Order and Zero-Order
2.9K
Eliminating drugs from the body is a vital process that occurs through excretion or metabolism. Understanding the kinetics of drug elimination is crucial for drug development, dosage determination, and optimizing patient outcomes.
Drug clearance depends on the rate of drug elimination and its plasma concentration. Another important parameter is a drug's half-life, which is the time required for its concentration to decrease by half. In most cases, drug clearance follows first-order...
Drug clearance depends on the rate of drug elimination and its plasma concentration. Another important parameter is a drug's half-life, which is the time required for its concentration to decrease by half. In most cases, drug clearance follows first-order...
2.9K
Elimination Reactions
17.0K
A nucleophile can react with an alkyl halide to give the substitution product by displacing the halogen. Or it can function as a base to give the elimination product by deprotonation of the neighboring carbon to form an alkene. In an elimination reaction, the substrate loses two groups from adjacent carbons forming at least one π bond. The carbon attached to the halogen is called the α carbon, while the adjacent carbon is called the β carbon; hence, these reactions are called...
17.0K
Radical Formation: Elimination
2.4K
Another method of radical formation is the elimination process. It is the opposite of the addition route and is driven by the instability of the radical. For example, as depicted in Figure 1, dibenzoyl peroxide yields a pair of unstable radicals upon homolysis. Given its instability, this radical spontaneously undergoes elimination via a C–C bond cleavage to form a relatively more stable phenyl radical. The mechanism involves cleavage of the bond between the α and β positions with respect...
2.4K
Gaussian Elimination: Problem Solving
194
Systems of linear equations in several variables are pivotal in modeling complex scenarios involving multiple unknowns and constraints. Such systems are widely used in various fields to represent relationships where several conditions must be simultaneously satisfied. Each variable in the system corresponds to an unknown quantity, while each equation imposes a linear constraint, leading to a structured approach for analyzing and solving real-world problems.A system of three equations with three...
194
Kinetics of Drug Elimination
4.2K
Eliminating drugs from the body is a vital process that occurs through excretion or metabolism. Understanding the kinetics of drug elimination is crucial for drug development, dosage determination, and optimizing patient outcomes.
Drug clearance depends on the rate of drug elimination and its plasma concentration. Another important parameter is the half-life of a drug, which is the time required for its concentration to decrease by half. In most cases, drug clearance follows first-order...
Drug clearance depends on the rate of drug elimination and its plasma concentration. Another important parameter is the half-life of a drug, which is the time required for its concentration to decrease by half. In most cases, drug clearance follows first-order...
4.2K
Enhanced Elimination of Poison
910
Poison can be effectively removed from the gastrointestinal (GI) tract through various decontamination procedures.
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...
910


