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Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
Published on: May 16, 2025
Therapy for Proliferative Lupus Nephritis
Kristin Meliambro1, Kirk N Campbell1, Miriam Chung1
1Division of Nephrology, Icahn School of Medicine at Mount Sinai, Box 1243, One Gustave L. Levy Place, New York, NY 10029, USA.
Abstract:
Proliferative lupus nephritis requires prompt diagnosis and treatment with immunosuppressive therapy. Cyclophosphamide is the longest studied agent, but mycophenolate mofetil has recently emerged as an efficacious induction and maintenance treatment that does not impart the risk of infertility. However, overall remission rates remain suboptimal and there is a need for improved therapeutic options. To this end, ongoing clinical studies are focusing on agents that target key molecules and pathways implicated in the pathogenesis of lupus nephritis based on previous animal and human studies. This article reviews key findings of trials supporting established induction and maintenance treatment regimens along with novel therapeutic investigations.
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