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Related Experiment Video

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Dr. Lahti-Pulkkinen et al. Reply.

Marius Lahti-Pulkkinen1, Polina Girchenko2, Katri Räikkönen2

  • 1University of Helsinki, Finland; University of Edinburgh, UK.

Journal of the American Academy of Child and Adolescent Psychiatry
|October 3, 2018
PubMed
Summary

Unaccounted confounders may influence links between prenatal depression and child psychiatric issues. Our study found no association with epigenetic age, suggesting other factors are not relevant in this context.

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Area of Science:

  • Reproductive Psychiatry
  • Developmental Neuroscience
  • Epigenetics

Background:

  • The relationship between maternal antenatal depression and child psychiatric problems is complex.
  • Epigenetic gestational age has emerged as a potential biomarker in this context.
  • Previous research suggested associations between epigenetic age, maternal depression, and child outcomes.

Discussion:

  • Ghosh et al. proposed unaccounted confounders like substance use and socioeconomic status may explain observed associations.
  • These factors are acknowledged as significant contributors to maternal and child psychopathology.
  • However, in our sample, these specific covariates were not associated with child epigenetic gestational age.

Key Insights:

  • The study did not adjust for maternal substance use or socioeconomic factors due to their lack of association with epigenetic gestational age in the sample.
  • This addresses concerns raised about potential confounding variables.
  • The findings support the specific associations reported in the original study within the studied population.

Outlook:

  • Further research should explore diverse populations to validate these epigenetic findings.
  • Investigating the interplay of various environmental and biological factors is crucial.
  • Longitudinal studies can elucidate the developmental trajectories of children exposed to antenatal depression.