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Regional Differences in Human Intestinal Drug Metabolism

Raditya Iswandana1, Marina I Irianti1, Dorenda Oosterhuis1

  • 1Division of Pharmaceutical Technology and Biopharmacy (R.I., M.I.I., D.O., H.A.M.M., P.O.) and Division of Pharmacokinetics, Toxicology and Targeting (M.T.M., M.H.d.J.), Department of Pharmacy, University of Groningen, Groningen, The Netherlands; Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia (R.I.); Department of Surgery, University Medical Center Groningen, Groningen, The Netherlands (H.S.H.); and Department of Clinical Medicine, Aarhus University, Aarhus, Denmark (H.A.M.M.).

Drug Metabolism and Disposition: the Biological Fate of Chemicals
|October 3, 2018
PubMed
Summary

Human intestines show distinct drug metabolism patterns. Phase I metabolism is concentrated in the ileum, while Phase II metabolism occurs mainly in the colon, with some sex-based variations observed.

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