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Up-regulation of Bone Morphogenetic Protein 7 by 2-Hydroxycinnamaldehyde Attenuates HNSCC Cell Invasion

Sung-Min Kang1, Jinkyung Kim1, Soo Hyun Kang1

  • 1Department of Microbiology and Immunology, School of Dentistry, Kyungpook National University, Daegu, Republic of Korea.

Anticancer Research
|October 3, 2018
PubMed
Abstract

Insights

2-hydroxycinnamaldehyde (HCA) inhibits head and neck squamous cell carcinoma (HNSCC) invasion by upregulating BMP7. This study confirms BMP7

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • Head and neck squamous cell carcinoma (HNSCC) invasion is a critical factor in patient prognosis.
  • The anti-cancer properties of 2'-hydroxycinnamaldehyde (HCA) are being investigated.
  • The role of Bone Morphogenetic Protein 7 (BMP7) in HNSCC progression requires further elucidation.

Purpose of the Study:

  • To investigate the effect of HCA on HNSCC cell migration and invasion.
  • To determine the role of BMP7 in mediating the anti-invasive activity of HCA.

Main Methods:

  • Cell migration and invasion were assessed using wound healing and Matrigel assays.
  • Gene expression of BMP7 was manipulated using overexpression vectors and siRNA.
  • Protein and mRNA levels of BMP7 were analyzed following HCA treatment.

Main Results:

  • HCA significantly reduced HNSCC cell migration and invasion without inducing cytotoxicity.
  • HCA treatment led to increased mRNA and protein expression of BMP7.
  • BMP7 overexpression alone inhibited cell invasion, while BMP7 suppression abolished HCA's anti-invasive effect.

Conclusions:

  • 2'-hydroxycinnamaldehyde (HCA) effectively inhibits HNSCC cell invasion.
  • The anti-migratory and anti-invasive effects of HCA are mediated through the upregulation of BMP7.
  • BMP7 is a key molecular player in HCA's anti-cancer activity against HNSCC.
Keywords:
2’-hydroxycinnamaldehydeHead and neck squamous cell carcinomaMatrigel invasionbone morphogenetic protein 7

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