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Updated: Feb 4, 2026

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
Published on: July 6, 2017
Prognostic Significance and Clinicopathological Features of Synchronous Colorectal Cancer
Keiichi Arakawa1, Keisuke Hata2, Hiroaki Nozawa2
1Department of Surgical Oncology, the University of Tokyo Hospital, Tokyo, Japan keiichiarakawa@hotmail.com.
Aim:
This study aimed to clarify the difference in the clinicopathological and prognostic features between synchronous colorectal cancer (CRC) and solitary CRC.
Materials And Methods:
A retrospective analysis was conducted in patients with synchronous and solitary CRC.
Results:
A total of 92 (7.1%) out of 1,295 consecutive patients had synchronous CRC. Mucinous adenocarcinoma was more frequent in patients with synchronous CRC than in those with solitary CRC (13.0% vs. 3.7%; p<0.001). The 5-year relapse-free survival (RFS) rate was poorer in patients with synchronous CRC than in those with solitary CRC (65.3% vs. 75.1%; p=0.035), which was contrived by the multivariate analysis (hazard ratio=1.52(HR); p=0.039).
Conclusion:
Patients with synchronous CRC had a poorer RFS than those with solitary CRC; thus, patients with synchronous CRC might require more intensive care than those with solitary CRC in follow-up.
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