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Updated: Feb 4, 2026

Determining Glucose Metabolism Kinetics Using 18F-FDG Micro-PET/CT
Published on: May 2, 2017
SUVmax-based Parameters of FDG-PET/CT Reliably Predict Pathologic Complete Response After Preoperative
Hiroto Murata1,2,3, Masahiko Okamoto4, Takeo Takahashi5
1Department of Radiation Oncology, Gunma University Graduate School of Medicine, Gunma, Japan.
Background/Aim:
To determine the most reliable predictor for pathologic complete response (pCR) in patients who underwent preoperative chemoradiotherapy and regional hyperthermia (HCRT) for rectal cancer.
Patients And Methods:
Thirty-six patients were enrolled. The local control status of the patients was assessed using 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT), magnetic resonance imaging (MRI), and colonoscopy before and after HCRT. The relationships between various parameters of these clinical examinations and pCR were analyzed.
Results:
Ten (28%) patients achieved pCR. The accuracies of predicting pCR using FDG-PET/CT, MRI, and colonoscopy were 78%, 61%, and 75%, respectively. FDG-PET/CT was the only independent predictive modality for pCR (p=0.021). The maximum standardized uptake value (SUVmax) and SUVmax normalized to liver uptake (SLR) after HCRT showed the highest sensitivity (90%) and the decreasing rate of SUVmax and SLR demonstrated the highest specificity (89%) for pCR.
Conclusion:
SUVmax-based parameters of FDG-PET/CT after HCRT were the most reliable predictors for pCR.
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