Related Experiment Video

Updated: Feb 4, 2026

Assessing Specificity of Anticancer Drugs In Vitro
09:39

Assessing Specificity of Anticancer Drugs In Vitro

Published on: March 23, 2016

9.8K

Accelerating anticancer drug development - opportunities and trade-offs

Sharyl J Nass1, Mace L Rothenberg2, Rebecca Pentz3

  • 1Health and Medicine Division, National Academies of Sciences, Engineering and Medicine, Washington, DC, USA. snass@nas.edu.

Nature Reviews. Clinical Oncology
|October 3, 2018
PubMed

Insights

Precision medicine in oncology requires adaptive drug development. Novel trial designs and data strategies can accelerate therapeutic access while ensuring safety and efficacy information is continuously gathered.

Area of Science:

  • Oncology
  • Drug Development
  • Clinical Trials

Background:

  • Traditional oncology drug development faces challenges with the rise of precision medicine and patient stratification.
  • The precision medicine paradigm necessitates more adaptive and efficient clinical trial designs.

Purpose of the Study:

  • To explore novel strategies for improving the efficiency of oncology drug development.
  • To identify new mechanisms for gathering information on anticancer therapies throughout their lifecycle.

Main Methods:

  • Review of current drug development paradigms in oncology.
  • Discussion of novel trial designs and modeling strategies.
  • Exploration of innovative data acquisition methods like functional imaging and real-world data.

Main Results:

  • Seamless trial designs offer accelerated access to novel oncology therapeutics.
  • Trade-offs include limited early-stage information on clinical benefit and safety.
  • Opportunities exist to enhance efficiency and data collection throughout the drug lifecycle.

Conclusions:

  • Adaptive and seamless approaches are crucial for modern oncology drug development.
  • Integrating novel trial designs, modeling, imaging, and real-world data can optimize drug development efficiency and information gathering.

More Related Videos

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles08:03

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

9.5K
Author Spotlight: Scalable Drug Screening Protocol for Efficient Discovery of M. abscessus Treatments07:50

Author Spotlight: Scalable Drug Screening Protocol for Efficient Discovery of M. abscessus Treatments

Published on: October 25, 2024

2.4K

Related Concept Videos

Accelerators01:17

Accelerators

Accelerators in concrete serve as admixtures to speed up the hardening process, enabling the concrete to achieve early strength faster. Although accelerators do not necessarily impact the time it takes concrete to set, they reduce this time in practice. A common accelerator is calcium chloride, which is particularly useful for hastening early strength development in cold weather or for rapid repair jobs that require quick heat generation after mixing.
The effectiveness of calcium chloride can...
290
Average Acceleration01:30

Average Acceleration

The importance of understanding acceleration spans our day-to-day experiences, as well as the vast reaches of outer space and the tiny world of subatomic physics. In everyday conversation, to accelerate means to speed up. For instance, we are familiar with the acceleration of our car; the harder we apply our foot to the gas pedal, the faster we accelerate. The greater the acceleration, the greater the change in velocity over a given time. Acceleration is widely seen in experimental physics. In...
14.0K
Instantaneous Acceleration01:16

Instantaneous Acceleration

Acceleration is in the direction of the change in velocity, but it is not always in the direction of motion. When an object slows down, its acceleration is opposite to the direction of its motion. Although commonly referred to as deceleration, this causes confusion in our analysis as deceleration is not a vector, and does not point to a specific direction with respect to a coordinate system. Therefore, the term deceleration is not used. For example, when a subway train slows down, it...
23.2K
Acceleration Vectors01:30

Acceleration Vectors

In everyday conversation, accelerating means speeding up. Acceleration is a vector in the same direction as the change in velocity, Δv, therefore the greater the acceleration, the greater the change in velocity over a given time. Since velocity is a vector, it can change in magnitude, direction, or both. Thus acceleration is a change in speed or direction, or both. For example, if a runner traveling at 10 km/h due east slows to a stop, reverses direction, and continues their run at 10 km/h...
22.8K
Accelerating Fluids01:17

Accelerating Fluids

When a fluid is in constant acceleration, the pressure and buoyant force equations are modified. Suppose a beaker is placed in an elevator accelerating upward with a constant acceleration, a. In the beaker, assume there is a thin cylinder of height h with an infinitesimal cross-sectional area, ΔS.
The motion of the liquid within this infinitesimal cylinder is considered to obtain the pressure difference. Three vertical forces act on this liquid:
2.3K
Acceleration due to Gravity on Other Planets01:24

Acceleration due to Gravity on Other Planets

The gravitational acceleration of an object near the Earth's surface is called the acceleration due to gravity. It can be measured by conducting simple experiments on Earth. However, such an experiment is impossible to conduct on the surface of other planets.
Astronomical observations are thus used to measure the acceleration due to gravity on other planets. This can be determined by observing the effect of a planet's gravity on objects close to it. The crucial factor that helps in this...
5.0K