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Specific antigen-Ia activation of transfected human T cells expressing murine Ti alpha beta-human T3 receptor

T Saito, A Weiss, J Miller

    Nature
    |January 8, 1987
    PubMed

    The genes encoding the alpha and beta chains of the T-cell receptor (Ti) of an antigen-specific, Ia-restricted murine T-cell hybridoma were introduced into T3-positive or T3-negative human T cells. The resultant transfectants express either mouse-human or mouse-mouse Ti alpha beta molecules functionally associated with the human T3 complex. Only the complete murine Ti alpha beta dimer mediates specific functional corecognition of the appropriate antigen-Ia pair.

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