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Related Experiment Video

Updated: Feb 4, 2026

Identifying Protein-protein Interaction Sites Using Peptide Arrays

Identifying Protein-protein Interaction Sites Using Peptide Arrays

Published on: November 18, 2014

Identifying fenofibrate responsive CpG sites.

Rita Cantor¹, Linda Navarro¹, Calvin Pan¹

¹Department of Human Genetics, David Geffen School of Medicine, University of California at Los Angeles, 695 Charles E. Young Dr. South, Los Angeles, CA USA.

BMC Proceedings

|October 3, 2018

Summary

This summary is machine-generated.

Fenofibrate treatment influences DNA methylation variability. This study identified specific cytosine-phosphate-guanine (CpG) sites in KIAA1804 and ANAPC2 genes that show drug-responsive methylation patterns, linked to genetic factors.

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Area of Science:

Genetics
Epigenetics
Pharmacogenomics

Background:

DNA methylation patterns can be influenced by environmental factors and genetic predisposition.
Understanding drug-specific methylation changes is crucial for personalized medicine.

Purpose of the Study:

To identify cytosine-phosphate-guanine (CpG) sites responsive to fenofibrate treatment.
To investigate the familiality and variability of methylation changes following fenofibrate administration.

Main Methods:

Analyzed DNA methylation at ~450,000 sites in pedigree members before and after 3 weeks of fenofibrate treatment.
Employed an indirect approach by examining genetic influences on methylation variability post-treatment.
Identified CpG sites with significant differences in sibling correlation and standard deviation pre- and post-treatment.

Main Results:

No significant methylation outliers were observed pretreatment.
Posttreatment, 16 outliers were identified in sibling correlation and standard deviation distributions.
Nearly 100% of sibling correlation distributions and 8% of standard deviation distributions differed significantly between pre- and post-treatment.
Identified methylation sites within the KIAA1804 and ANAPC2 genes.

Conclusions:

Fenofibrate treatment induces significant changes in DNA methylation variability at specific CpG sites.
Methylation levels at identified sites in KIAA1804 and ANAPC2 are strongly influenced by genetic factors (methylation quantitative trait loci) and fenofibrate exposure.