The effects of combined aerobic and resistance training on inflammatory markers in obese men

It is important to treat obesity and the related noncommunicable diseases. The main objective of this study is the effect of different training types on inflammatory and immune markers in obesity. Seventeen obese men with body mass index (BMI)≥26 kg/m² were randomly divided into two groups: aerobic training group (AT; n=9) and combined aerobic and resistance training group (CT; n=8). Body composition (weight, BMI, %body fat), factors of physical performance (one-repetition maximum [1RM], maximal oxygen uptake [VO_2max]), inflammatory markers (interleukin-6, tumor necrosis factor-alpha [TNF-α]), immune markers (leukocyte, natural killer cell) were analyzed before and after 8-week training. Body composition (weight, BMI, and %body fat) was significantly reduced after training in both the AT and CT groups (P<0.05). As a result of training, VO_2max of all training groups was increased and 1RM of CT group was partially improved. In particular, the inflammatory marker, TNF-α was significantly reduced (P<0.05) and the change was correlated with %body fat in the posttraining CT group. In this study, we found that combined training for 8 weeks improved physical fitness, body composition, and inflammation. It is suggested that restoring obesity through combined training of aerobic and resistance exercise is related to changes in serum TNF-α levels.