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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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In vitro Labeling of Human Embryonic Stem Cells for Magnetic Resonance Imaging
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Tracking mesenchymal stem cells using magnetic resonance imaging.

Jens T Rosenberg1,2, Xuegang Yuan2, Samuel Grant1,2

  • 1Department of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering, Florida State University, Tallahassee, FL 32310, USA.

Brain Circulation
|October 3, 2018
PubMed
Summary
This summary is machine-generated.

Superparamagnetic iron oxide (SPIO) nanoparticles effectively label mesenchymal stem cells (MSCs) for MRI tracking without impacting cell function. This method enhances cell tracking for neurodegenerative disease therapies.

Keywords:
Cell trackinghuman mesenchymal stem cellshypoxiaischemiamagnetic resonance imagingsuperparamagnetic iron oxide

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Area of Science:

  • * Regenerative Medicine
  • * Cell Therapy
  • * Neuroimaging

Background:

  • * Mesenchymal stem cells (MSCs) show promise for treating neurological disorders like stroke and Parkinson's disease.
  • * Accurate tracking of transplanted MSCs is crucial for optimizing cell therapy efficacy.
  • * Current histological tracking methods are invasive and limit repeat evaluations.

Purpose of the Study:

  • * To review the effects of superparamagnetic iron oxide (SPIO) nanoparticle uptake on human MSCs.
  • * To assess the influence of SPIO concentration on MRI sensitivity for cell tracking.
  • * To evaluate the potential of SPIO-labeled MSCs for noninvasive, long-term monitoring in vivo.

Main Methods:

  • * Review of existing literature on SPIO labeling of MSCs.
  • * Analysis of studies investigating SPIO effects on MSC proliferation and differentiation.
  • * Examination of animal model studies using SPIO-labeled MSCs for MRI tracking.

Main Results:

  • * SPIO uptake does not affect MSC proliferation or differentiation.
  • * SPIO labeling significantly enhances MRI contrast for cell visualization.
  • * SPIO-labeled MSCs demonstrate stable MRI contrast in animal models, indicating lasting detectability.

Conclusions:

  • * SPIO labeling is a viable strategy for noninvasive MRI tracking of MSCs.
  • * This technique can improve the understanding of MSC fate and distribution in cell therapies.
  • * SPIO-labeled MSCs offer potential for enhanced monitoring in regenerative medicine for neurological conditions.