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Progress in targeted therapy for breast cancer

Jie Ju1, An-Jie Zhu1, Peng Yuan2

  • 1Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Chronic Diseases and Translational Medicine
|October 3, 2018
PubMed

Insights

Targeted therapy has revolutionized breast cancer treatment by focusing on specific pathways like hormone receptor and HER2. This review highlights recent advancements and challenges in precision medicine for breast cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Breast cancer is a complex, heterogeneous disease with evolving treatment strategies.
  • Understanding cancer pathogenesis has identified numerous signaling pathways and therapeutic targets.

Purpose of the Study:

  • To review the latest advancements in targeted therapy for breast cancer.
  • To discuss current challenges and future directions in the field.

Main Methods:

  • Literature review of recent studies on targeted therapies for breast cancer.
  • Analysis of key signaling pathways and their targeted agents.
  • Discussion of clinical trial outcomes and resistance mechanisms.

Main Results:

  • Targeted therapies, including those against hormone receptor, HER2, CDK4/6, and PARP, have significantly improved outcomes.
  • Precision medicine approaches are increasingly important in breast cancer management.
  • Emerging targets and resistance mechanisms require further investigation.

Conclusions:

  • Targeted therapy is a cornerstone of modern breast cancer treatment, enhancing efficacy and reducing toxicity.
  • Continued research into novel targets and overcoming resistance is crucial for advancing breast cancer care.
Keywords:
Breast cancerPrecision medicineTargeted therapy

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