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Updated: Feb 4, 2026

Gold Nanoparticle Synthesis
Published on: July 10, 2021
Synthesis of novel heteroleptic delocalised cationic pyrazole gold complexes as potent HepG2 cytotoxic agents
Fatai Afolabi1, Wided Souissi, Guillaume Rivière
1Department of Chemistry, School of Life Sciences, University of Sussex, Brighton, BN1 9QJ, UK. E.M.E.Viseux@sussex.ac.uk.
Abstract:
A new series of cationic gold(i) pyrazole complexes were prepared in excellent yields as their perchlorate salts. Results of cell viability assays show that these novel complexes have good cytotoxic properties against the human HepG2 cancer cell line. These complexes showed promising anti-cancer activities and to our knowledge, pyrazoles have never been tested against this cell line. The regioselectivity of the complexation is also discussed in regards to the substitution pattern of the pyrazoles.
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