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Use of the Protease Fluorescent Detection Kit to Determine Protease Activity

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Proteases: Pivot Points in Functional Proteomics.

Ingrid M Verhamme¹, Sarah E Leonard², Ray C Perkins³

¹Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA. Ingrid.verhamme@vanderbilt.edu.

Methods in Molecular Biology (Clifton, N.J.)

|October 3, 2018

Summary

This summary is machine-generated.

Proteases are essential enzymes regulating protein life cycles and cellular functions. Their dysregulation is linked to numerous diseases, making them key targets for novel therapeutics and biomarkers.

Keywords:

Autoimmune disease Biomarker development Cancer Cardiovascular disease Cell migration Cell proliferation Complement system Cytosolic proteolysis DNA processing DNA repair DNA replication Digestion Drug development Drug target Epigenetics Hemostasis Immune regulation Infectious organisms Inflammation Intramembrane proteolysis Intranuclear proteolysis Metabolic disease Neurodegenerative disease Peptidase Precision medicine Programmed cell death Protease Protease inhibitor Protease promoter Protein secretion Proteolysis Signaling Stroke Transmembrane proteolysis

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Area of Science:

Biochemistry
Molecular Biology
Systems Biology

Background:

Proteases are critical enzymes involved in protein processing, from activation to degradation.
Beyond digestion, proteases play fundamental roles in physiological regulation and cellular homeostasis.
Proteolytic activity is closely linked to various diseases, presenting therapeutic opportunities.

Purpose of the Study:

To examine the pivotal roles of proteolysis in physiological processes and diseases.
To detail the impact of proteolysis on drug and biomarker development.
To provide a comprehensive overview of protease functions across four major categories and 23 subcategories.

Main Methods:

Analysis of proteolysis across diverse physiological and pathological contexts.
Compilation and cross-comparison of 15 datasets on proteases, inhibitors, and substrates.
Review of over 300 references to support findings.

Main Results:

Proteases are implicated in fundamental physiological processes and disease pathogenesis.
Data reveal intersections between proteases, inhibitors, substrates, and various diseases.
Specific examples highlight protease involvement in hemostasis, immunity, cardiovascular disease, cancer, and neurodegeneration.

Conclusions:

Proteases act as crucial pivot points in functional proteomics.
Modulating proteolytic activity holds significant therapeutic and diagnostic potential.
The study underscores the broad and interconnected roles of proteases in health and disease.