Renal cell carcinoma and pathologic nodal disease: Implications for American Joint Committee on Cancer staging

Lymph node (LN) metastases are associated with poor outcomes for patients with renal cell carcinoma (RCC). This study compared the survival outcomes of patients with stage III, node-positive disease (pT₁₂₃ N₁ M₀ ) and patients with stage III, node-negative disease (pT₃ N₀ M₀ ).

A database of 4652 patients with RCC of any histological subtype treated with surgery at The University of Texas MD Anderson Cancer Center from 1993 to 2012 was retrospectively assessed. A total of 115 patients with pT₁₂₃ N₁ M₀ disease, 274 patients with pT₃ N₀ M₀ disease, and 523 patients with pT₁₂₃ N_0/x M₁ disease were included. Overall survival (OS) and cancer-specific survival (CSS) were estimated and compared between each cohort.

Median OS and CSS times were significantly better for pT₃ N₀ M₀ patients than pT₁₂₃ N₁ M₀ patients (OS, 10.2 vs 2.4 years, P < .0001; CSS, not reached vs 2.8 years, P < .0001). Similar median OS and CSS times were noted for pT₁₂₃ N₁ M₀ and pT₁₂₃ N_0/x M₁ patients (OS, 2.4 vs 2.4 years; P = .62; CSS, 2.8 vs 2.4 years; P = .10). In a multivariate analysis, tumor grade (hazard ratio [HR] for OS, 2.47; P < .0001; HR for CSS, 2.99; P < .0001) and pathologic LN involvement (HR for OS, 2.44; P < .0001; HR for CSS, 2.85; P < .0001) were associated with worse OS and CSS.

Among RCC patients classified with stage III disease, those with pT₁₂₃ N₁ M₀ disease had significantly worse survival than those with pT₃ N₀ M₀ disease. OS and CSS were similar for patients with pT₁₂₃ N₁ M₀ disease and patients with pT₁₂₃ N_0/x M₁ disease (stage IV). If validated, these findings suggest that RCC patients with nodal disease should be reclassified as having stage IV disease.