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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Protein Networks02:26

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An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
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Archival Research01:40

Archival Research

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Some researchers gain access to large amounts of data without interacting with a single research participant. Instead, they use existing records to answer various research questions. This type of research approach is known as archival research. Archival research relies on looking at past records or data sets to look for interesting patterns or relationships. For example, a researcher might access the academic records of all individuals who enrolled in college within the past ten years and...
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Generation of Comprehensive Thoracic Oncology Database - Tool for Translational Research
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LncRNAnet: a comprehensive Sus scrofa lncRNA database.

G Liang1, Y Yang1,2,3, H Li1

  • 1College of Life Science, Foshan University, 1 Xianhu University Road, Nanhai, Foshan, Guangdong, 528231, China.

Animal Genetics
|October 3, 2018
PubMed
Summary

A new database, lncRNAnet, catalogs 53,468 pig long noncoding RNAs (lncRNAs). This resource aids research into pig lncRNA function and evolution, integrating human and mouse data for comparative analysis.

Keywords:
expression profilelong non-coding RNApigtissue-specific expression

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Area of Science:

  • Genomics
  • Bioinformatics
  • Molecular Biology

Background:

  • Long noncoding RNAs (lncRNAs) are crucial functional non-coding RNAs involved in diverse biological processes.
  • Mammals possess thousands of identified lncRNAs, highlighting their evolutionary significance.
  • Pigs (Sus scrofa) are vital agricultural animals and valuable biomedical models, necessitating dedicated genomic resources.

Purpose of the Study:

  • To construct a comprehensive database for Sus scrofa lncRNAs to facilitate functional and evolutionary studies.
  • To provide a centralized resource for pig lncRNA data, including sequence characteristics, genomic location, conservation, and expression patterns.
  • To enable comparative analysis by integrating human and mouse lncRNA data.

Main Methods:

  • Systematic identification and compilation of Sus scrofa lncRNAs.
  • Annotation of lncRNA features: sequence characteristics, genomic locations, conservation, overlapping SNPs and QTLs.
  • Integration of transcript abundance data across nine pig tissues.
  • Inclusion of human and mouse lncRNA sequences for cross-species comparison.

Main Results:

  • Development of lncRNAnet, a database containing 53,468 S. scrofa lncRNAs.
  • Detailed annotation of each lncRNA, including sequence properties, genomic context, and expression levels.
  • Integration of 212,922 human and mouse lncRNA sequences.
  • Establishment of a platform for systematic lncRNA classification and analysis.

Conclusions:

  • lncRNAnet provides a valuable resource for pig lncRNA research.
  • The database supports browsing, searching, and BLAST analysis of pig, human, and mouse lncRNAs.
  • lncRNAnet is expected to significantly advance the understanding of lncRNA biological functions and evolution in pigs.