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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Changes in the inflammatory and oxidative stress markers during a single hemodialysis session in patients with
B Sangeetha Lakshmi1, N Harini Devi2, M M Suchitra2
1a Department of Nephrology , Sri Venkateswara Institute of Medical Sciences , Tirupati, India.
Insights
Hemodialysis (HD) patients show increased inflammation and oxidative stress markers, including Pentraxin-3, hs-CRP, and MDA, with decreased antioxidant FRAP levels post-procedure. This suggests HD contributes to these harmful processes in end-stage renal disease.
Area of Science:
- Nephrology
- Cardiovascular Medicine
- Biochemistry
Background:
- Cardiovascular disease (CVD) is a major cause of mortality in end-stage renal disease (ESRD) patients undergoing hemodialysis (HD).
- Oxidative stress and inflammation are identified as key non-traditional risk factors contributing to CVD progression in HD patients.
- Previous studies suggest a potential increase in inflammatory and oxidative stress markers during HD sessions.
Purpose of the Study:
- To evaluate the impact of a single hemodialysis session on inflammatory and oxidative stress markers in chronic kidney disease patients.
- To compare these markers in ESRD patients before and after HD with a healthy control group.
Main Methods:
- Inclusion of 25 ESRD patients on maintenance HD and 25 healthy controls.
- Collection of blood samples pre- and post-HD from patients.
- Measurement of serum Pentraxin-3, high-sensitivity C-reactive protein (hs-CRP), malondialdehyde (MDA), and ferric reducing ability of plasma (FRAP) levels.
Main Results:
- HD patients exhibited elevated levels of Pentraxin-3, hs-CRP, and MDA compared to controls.
- A decrease in the ferric reducing ability of plasma (FRAP) was observed in HD patients.
- These findings indicate significant changes in oxidative and inflammatory markers during hemodialysis.
Conclusions:
- The hemodialysis procedure itself appears to contribute to increased inflammation and oxidative stress.
- These findings highlight the procedural impact on the heightened cardiovascular risk in ESRD patients undergoing HD.
Background:
Cardiovascular disease (CVD) is a common cause of morbidity and mortality in end-stage renal disease (ESRD) patients on hemodialysis (HD) among whom it is 5-20 times higher than in the general population. Some of the nontraditional risk factors such as oxidative stress and inflammation are related to the progress of CVD in HD patients. Several, but not all studies, reported that inflammatory and oxidative stress markers are increased during a single session of HD, mimicking changes that occur during acute immune activation. This study was taken up to evaluate the changes in the inflammatory and oxidative stress markers during a single HD session in patients with chronic kidney disease.
Methods:
Twenty-five ESRD patients on maintenance HD and 25 controls were included in the study. Blood samples were obtained from the patients before starting of hemodialysis (pre-HD) and after completion of hemodialysis (post-HD). The changes in serum Pentraxin-3, hs-CRP, malondialdehyde (MDA) and ferric reducing ability of plasma (FRAP) levels were measured in pre- and post-HD ESRD patients and compared with healthy control group.
Results:
This study found increased levels of Pentraxin-3, hs-CRP, MDA, and decreased level of FRAP in HD patients compared to controls.
Conclusions:
Hemodialysis procedure contributes to inflammation and oxidative stress.
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