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Profiling Thiol Redox Proteome Using Isotope Tagging Mass Spectrometry
Published on: March 24, 2012
Thiol redox-sensitive cationic polymers for dual delivery of drug and gene
Priya Sahadevan Syamala1, Rekha Mannemcherril Ramesan1
1Division of Biosurface Technology, Biomedical Technology Wing, Sree Chitra Tirunal Institute of Medical Sciences & Technology, Poojappura, Thiruvananthapuram, Kerala.
Abstract:
Recently greater emphasis has been given to combination therapy for generating synergistic effects of treating cancer. Recent studies on thiol-sensitive nanocarriers for the delivery of drug or gene have shown promising results. In this review, we will examine the rationale and advantage in using nanocarriers for the combined delivery of different anticancer drugs and biologics. Here, we also discuss the role of nanocarriers, particularly redox-sensitive polymers in evading or inhibiting the efflux pump in cancer and how they modulate the sensitivity of cancer cells. The review aims to provide a good understanding of the new pattern of cancer treatment and key concerns for designing nanomedicine of synergistic combinations for cancer therapy.
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