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[Developmental Aspects of Senescence]

E Yu Brusentsev, M A Tikhonova, Yu E Herbeck

    Ontogenez
    |October 3, 2018
    PubMed

    Insights

    This review explores aging mechanisms, focusing on nervous system changes in mammals and humans. It examines animal models and interventions to slow aging and correct age-related disorders.

    Area of Science:

    • Gerontology
    • Neuroscience
    • Cellular Biology

    Background:

    • Aging is a complex biological process characterized by senescence.
    • Understanding aging mechanisms is crucial for addressing age-related health issues.

    Purpose of the Study:

    • To review different types of senescence and major aging theories.
    • To discuss the mechanisms underlying biological aging, with a focus on the nervous system.
    • To critically evaluate experimental models and interventions for age-related deterioration.

    Main Methods:

    • Literature review of senescence types and aging theories.
    • Analysis of age-related changes in mammalian and human nervous systems.
    • Examination of experimental animal models for aging research.
    • Review of interventions to correct age-related decline and alleviate disorders.

    Main Results:

    • Senescence involves diverse cellular and systemic changes.
    • The nervous system undergoes significant alterations with age.
    • Various experimental models exist for studying aging.
    • Potential interventions include chemical and other factors to slow senescence.

    Conclusions:

    • Aging is multifactorial, involving senescence and systemic changes.
    • The nervous system is a key focus for understanding aging.
    • Experimental models and interventions offer promise for mitigating age-related decline.

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