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In an underdamped second-order system, where the damping ratio ζ is between 0 and 1, a unit-step input results in a transfer function that, when transformed using the inverse Laplace method, reveals the output response. The output exhibits a damped sinusoidal oscillation, and the difference between the input and output is termed the error signal. This error signal also demonstrates damped oscillatory behavior. Eventually, as the system reaches a steady state, the error diminishes to zero.
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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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One year in review 2018: systemic sclerosis.

Martina Orlandi1, Simone Barsotti2, Gemma Lepri1

  • 1Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Florence, Italy.

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Summary

This review summarizes recent advancements in understanding systemic sclerosis (SSc), a rare autoimmune disease. It highlights key findings in SSc pathogenesis, diagnosis, and treatment from the past year.

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Area of Science:

  • Rheumatology
  • Immunology
  • Internal Medicine

Background:

  • Systemic sclerosis (SSc) is a rare autoimmune disease.
  • It is characterized by complex pathogenesis and multi-organ involvement.
  • Significant research efforts are dedicated to understanding SSc annually.

Purpose of the Study:

  • To provide an overview of recent literature on systemic sclerosis.
  • To highlight significant contributions to SSc knowledge over the last year.

Main Methods:

  • Literature review of scientific contributions.
  • Analysis of publications from the past year.

Main Results:

  • Recent literature has enriched the understanding of SSc pathogenesis.
  • New insights into clinical manifestations, diagnosis, and treatment of SSc have emerged.
  • The overview covers significant advancements in the field.

Conclusions:

  • The past year has seen substantial progress in SSc research.
  • Continued scientific contributions are vital for managing this severe disease.