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Three Dimensional Printed Bone Implants in the Clinic.

Nazzar Tellisi1, Nureddin A Ashammakhi2,3,4,5, Fabrizio Billi6

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Three-dimensional (3D) printing enables customized implants for personalized therapy. This technology, including 3D bioprinting, is advancing bone tissue engineering and surgical applications.

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Surgical Technology

Background:

  • Personalized therapy drives implant development.
  • Three-dimensional (3D) printing allows for customized, precisely fitting implants derived from 3D imaging.
  • Material combinations (e.g., ceramics, growth factors) enhance implant osteoconductivity and osteoinductivity.

Purpose of the Study:

  • To review the current applications and potential of 3D printing in creating customized implants.
  • To highlight advancements in 3D bioprinting for bone tissue engineering.
  • To discuss the clinical translation of 3D printed implants in maxillofacial and orthopedic surgery.

Main Methods:

  • Review of existing literature on 3D printing applications in implantology.
  • Discussion of material science principles for osteoconductive and osteoinductive implants.
  • Exploration of 3D bioprinting techniques for cell-laden constructs.

Main Results:

  • 3D printing facilitates the creation of patient-specific implants.
  • 3D bioprinting offers improved cell distribution in engineered tissues.
  • Clinical applications are currently limited but growing, primarily in maxillofacial and orthopedic surgery.

Conclusions:

  • 3D printing holds significant promise for personalized medicine through custom implant fabrication.
  • Wider clinical adoption of 3D printing will establish it as a key clinical tool.
  • Advancements in 3D bioprinting are crucial for future bone tissue engineering.