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Virtual Prism Adaptation Therapy: Protocol for Validation in Healthy Adults
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Is adaptive therapy natural?

Frédéric Thomas1, Emmanuel Donnadieu2,3,4, Guillaume M Charriere5

  • 1Centre de Recherches Ecologiques et Evolutives sur le Cancer/Maladies Infectieuses et Vecteurs: Ecologie, Génétique, Evolution, et Contrôle, CNRS, Université de Montpellier, Montpellier, France.

Plos Biology
|October 3, 2018
PubMed
Summary
This summary is machine-generated.

Integrating evolutionary principles into cancer treatment, known as natural adaptive therapy (NAT), can prolong progression-free survival by controlling resistant cancer cells. This approach aims to slow cancer evolution for long-term durable control.

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Area of Science:

  • Evolutionary biology
  • Cancer research
  • Immunology

Background:

  • Cancer progression is often driven by the evolution of resistant malignant cell populations.
  • Anticancer adaptations in organisms may include mechanisms to manage cancer evolution, not just prevent it.

Purpose of the Study:

  • To define and explore the concept of natural adaptive therapy (NAT).
  • To investigate how evolutionary principles can be integrated into cancer treatment protocols.
  • To identify potential risks associated with current immunotherapies.

Main Methods:

  • Conceptual development and theoretical exploration of natural adaptive therapy.
  • Analysis of ecological and evolutionary processes relevant to cancer.
  • Review of existing cancer treatment strategies and their evolutionary implications.

Main Results:

  • Natural adaptive therapy (NAT) proposes utilizing evolutionary processes to control cancer.
  • A restrained immune response may prevent the evolution of resistant cancer cells, promoting long-term control.
  • Aggressive immunotherapies that maximize short-term kill rates may accelerate cancer evolution and resistance.

Conclusions:

  • NAT offers a novel framework for cancer treatment by managing cancer evolution.
  • Understanding the body's natural adaptive therapy mechanisms could lead to new prevention and treatment strategies.
  • Caution is advised regarding immunotherapies that may inadvertently promote cancer resistance.