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Circular RNA Expression Profile and Analysis of Their Potential Function in Psoriasis
Meng Qiao1,2, Jian Ding3, Jianjun Yan1
1Department of Dermatology, Qilu Hospital of Shandong University, Jinan, China.
Summary
Circular RNAs (circRNAs) are implicated in diseases. This study found specific circRNAs, like hsa_circ_0061012, are upregulated in psoriasis, suggesting their role in the disease and potential as biomarkers.
Area of Science:
- Genomics
- Molecular Biology
- Dermatology
Background:
- Circular RNAs (circRNAs) are non-coding RNAs involved in various diseases.
- The specific role of circRNAs in the pathogenesis of psoriasis is not well understood.
Purpose of the Study:
- To investigate circRNA expression profiles in psoriasis.
- To analyze the potential functions and regulatory roles of circRNAs in psoriasis.
Main Methods:
- Differential circRNA expression analysis using the SBC human ceRNA array V1.0.
- Functional enrichment analysis via Gene Ontology (GO) and KEGG pathway analysis.
- Validation of key circRNAs using quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR).
Main Results:
- Identification of 4956 differentially expressed circRNAs in psoriatic lesions compared to healthy skin.
- Discovery of 4405 miRNA response elements (MREs) within differentially expressed circRNAs.
- Upregulation of hsa_circ_0061012 in psoriasis, with identified target miRNAs including hsa-miR-7157-5p and others.
Conclusions:
- hsa_circ_0061012 emerges as a potential diagnostic biomarker for psoriasis.
- Findings offer insights into ceRNA-mediated gene regulation in psoriasis.
- Provides a foundation for future research on circRNA functions in psoriasis pathogenesis.
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