Related Experiment Video

Updated: Feb 4, 2026

A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology
08:36

A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology

Published on: March 17, 2016

8.5K

Circular RNA Expression in the Brain of a Neonatal Rat Model of Periventricular White Matter Damage

Lihua Zhu1, Ruibin Zhao2, Li Huang3

  • 1Institute of clinical, Jiangsu Health Vocational College, Nanjing, China.

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
|October 3, 2018
PubMed

Insights

Periventricular white matter damage (PWMD) in preterm infants involves altered circular RNA (circRNA) expression in brain tissue. These circRNAs may serve as novel diagnostic and therapeutic targets for PWMD.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genomics

Background:

  • Periventricular white matter damage (PWMD) is a primary neurological injury in surviving preterm infants.
  • Understanding the molecular mechanisms underlying PWMD is crucial for developing effective treatments.

Purpose of the Study:

  • To investigate global changes and characteristics of circular RNA (circRNA) expression in rat brains with PWMD.
  • To identify potential diagnostic and therapeutic targets for PWMD.

Main Methods:

  • Deep RNA sequencing was used to compare circRNA expression profiles in PWMD rat brains versus control tissues.
  • Bioinformatics, quantitative reverse-transcription polymerase chain reaction (qRT-PCR), Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed.
  • Network analysis predicted circRNA-microRNA-target gene interactions.

Main Results:

  • 2151 circRNAs were dysregulated in PWMD brain tissues, with 52 over-expressed and 46 under-expressed among 98 significantly altered circRNAs.
  • Glutamatergic synapse and VEGF signaling pathways, linked to hypoxia/ischemia, were enriched.
  • Relationships between specific microRNAs (miRNAs) and HIF-1α, and potential associations with target genes, were identified.

Conclusions:

  • Distinct circRNA expression patterns indicate active response to hypoxia-ischemia in PWMD.
  • Identified circRNAs represent potential novel diagnostic and therapeutic targets for PWMD.
Abstract

Keywords:
Circular RNADeep RNA sequencingHypoxia-ischemiaPeriventricular white matter damagePremature birth

More Related Videos

Mouse Models of Periventricular Leukomalacia06:24

Mouse Models of Periventricular Leukomalacia

Published on: May 18, 2010

30.4K
Isolation of Neural Stem/Progenitor Cells from the Periventricular Region of the Adult Rat and Human Spinal Cord08:26

Isolation of Neural Stem/Progenitor Cells from the Periventricular Region of the Adult Rat and Human Spinal Cord

Published on: May 14, 2015

13.1K

Related Concept Videos

Classifying Matter by State02:49

Classifying Matter by State

Chemistry is the study of matter and the changes it undergoes. Matter is anything that has mass and occupies space. Matter is all around us; the air, water, soil, mountains, even our bodies are all examples of matter. Matter is divided into three states — solid, liquid, and gas — that are commonly found on earth. The fourth state of matter, plasma, occurs naturally in the interiors of stars. 
103.6K
Classifying Matter by Composition03:35

Classifying Matter by Composition

Matter: Pure Substances and Mixtures
According to its composition, the matter can be classified into two broad categories — pure substances and mixtures. 
A pure substance is a form of matter that has a constant composition throughout with uniform properties. For example, any sample of sucrose has the same composition and same physical properties, such as melting point, color, and sweetness, regardless of the source from which it is isolated. 
A mixture is composed of two or...
90.6K
Physical and Chemical Properties of Matter02:57

Physical and Chemical Properties of Matter

The characteristics that enable us to distinguish one substance from another are called properties.
166.5K
The Atomic Theory of Matter02:59

The Atomic Theory of Matter

The earliest recorded discussion of the basic structure of matter comes from ancient Greek philosophers. Leucippus and Democritus argued that all matter was composed of small, finite particles that they called atomos, meaning “indivisible.” Later, Aristotle and others came to the conclusion that matter consisted of various combinations of the four “elements” — fire, earth, air, and water — and could be infinitely divided. Interestingly, these philosophers...
128.2K
What is Matter?01:13

What is Matter?

The substance of the universe—from a grain of sand to a star—is called matter. Scientists define matter as anything that occupies space and has mass. An object’s mass and its weight are related concepts, but not quite the same. An object’s mass is the amount of matter contained in the object and is the same whether that object is on Earth or in the zero-gravity environment of outer space. An object’s weight, on the other hand, is its mass as affected by the pull of...
102.9K
States of Matter01:20

States of Matter

Solids, liquids, and gases are the three states of matter commonly found on Earth. A solid is rigid and possesses a definite shape. A liquid flows and takes the shape of its container, except it forms a flat or slightly curved upper surface when acted upon by gravity. Both liquid and solid samples have volumes nearly independent of pressure. A gas takes both the shape and volume of its container.
Scientists have discovered a fourth state of matter, plasma, that occurs naturally in the interiors...
2.9K